Literature DB >> 22238121

Genome-scale methylation analysis of Parkinson's disease patients' brains reveals DNA hypomethylation and increased mRNA expression of cytochrome P450 2E1.

Oliver Kaut1, Ina Schmitt, Ullrich Wüllner.   

Abstract

Multiple lines of evidence suggest a link between environmental toxins and Parkinson's disease (PD). Although numerous studies reported associations of genetic variants in de-toxifying enzymes, i.e. cytochrome genes, with PD. Epigenetic modifications of genes and subsequent altered expression may confer a yet unappreciated level of susceptibility. We present a genome-wide methylation analysis of PD with quantitative DNA methylation levels of 27.500 CpG sites representing 14.495 genes. We found decreased methylation of the cytochrome P450 2E1 gene and increased expression of CYP2E1 messenger RNA in PD patients' brains, suggesting that epigenetic variants of this cytochrome contribute to PD susceptibility.

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Year:  2012        PMID： 22238121     DOI： 10.1007/s10048-011-0308-3

Source DB:  PubMed          Journal:  Neurogenetics        ISSN： 1364-6745            Impact factor:   2.660


  17 in total

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3.  Co-localization of P450 enzymes in the rat substantia nigra with tyrosine hydroxylase.

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Review 5.  P450 enzymes and Parkinson's disease: the story so far.

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8.  Cytochrome P450 2E1 in the substantia nigra: relevance for dopaminergic neurotransmission and free radical production.

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  46 in total

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2.  Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates.

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4.  Epigenome-wide DNA methylation analysis in siblings and monozygotic twins discordant for sporadic Parkinson's disease revealed different epigenetic patterns in peripheral blood mononuclear cells.

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Review 5.  Not Just from Ethanol. Tetrahydroisoquinolinic (TIQ) Derivatives: from Neurotoxicity to Neuroprotection.

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7.  Aberrant NMDA receptor DNA methylation detected by epigenome-wide analysis of hippocampus and prefrontal cortex in major depression.

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Review 8.  Diallyl Sulfide: Potential Use in Novel Therapeutic Interventions in Alcohol, Drugs, and Disease Mediated Cellular Toxicity by Targeting Cytochrome P450 2E1.

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Journal:  Curr Drug Metab       Date:  2015       Impact factor: 3.731

Review 9.  Epigenetic Changes and Its Intervention in Age-Related Neurodegenerative Diseases.

Authors:  Nuraqila Mohd Murshid; Faridah Aminullah Lubis; Suzana Makpol
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10.  The role of epigenomics in personalized medicine.

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