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Literature DB >> 22237492

Testosterone and its metabolites--modulators of brain functions.

Jaroslava Durdiakova¹, Daniela Ostatnikova, Peter Celec.

Abstract

Testosterone is a steroid sex hormone with an important role in the physiology in both sexes. It is involved in the development of morphological and functional parameters of the body via multiple molecular mechanisms. Intensive research focused on testosterone reveals associations with cognitive abilities and behavior and its causative role in sex differences in cognition. Testosterone modulates brain structure and the differentiation of neurons during intrauterine development with profound effects on brain functions during postnatal life. In this review we summarize the effects of testosterone on brain physiology and cognition with respect to the underlying molecular mechanisms.

Entities: Chemical Disease

Mesh：

Substances：
Testosterone

Year: 2011 PMID： 22237492

Source DB: PubMed Journal: Acta Neurobiol Exp (Wars) ISSN： 0065-1400 Impact factor: 1.579

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Cited

17 in total

Review 1. Sex differences in anxiety and depression: role of testosterone.

Authors: Jenna McHenry; Nicole Carrier; Elaine Hull; Mohamed Kabbaj
Journal: Front Neuroendocrinol Date: 2013-09-24 Impact factor: 8.606

2. Characteristics associated with inter-individual differences in the trajectories of self-reported attentional function in oncology outpatients receiving chemotherapy.

Authors: Juliet Shih; Heather Leutwyler; Christine Ritchie; Steven M Paul; Jon D Levine; Bruce Cooper; Fay Wright; Yvette P Conley; Christine Miaskowski
Journal: Support Care Cancer Date: 2016-10-20 Impact factor: 3.603

Review 3. Testosterone deficiency, insulin-resistant obesity and cognitive function.

Authors: Hiranya Pintana; Nipon Chattipakorn; Siriporn Chattipakorn
Journal: Metab Brain Dis Date: 2015-02-24 Impact factor: 3.584

4. Axon diameter and axonal transport: In vivo and in vitro effects of androgens.

Authors: M Pesaresi; R Soon-Shiong; L French; D R Kaplan; F D Miller; T Paus
Journal: Neuroimage Date: 2015-05-06 Impact factor: 6.556

Review 5. Androgens and the cerebrovasculature: modulation of vascular function during normal and pathophysiological conditions.

Authors: Rayna J Gonzales
Journal: Pflugers Arch Date: 2013-04-21 Impact factor: 3.657

10. The Effects of Gender Differences in Patients with Depression on Their Emotional Working Memory and Emotional Experience.

Authors: Mi Li; Shengfu Lu; Gang Wang; Ning Zhong
Journal: Behav Neurol Date: 2015-10-22 Impact factor: 3.342

Testosterone and its metabolites--modulators of brain functions.

Review 1. Sex differences in anxiety and depression: role of testosterone.

2. Characteristics associated with inter-individual differences in the trajectories of self-reported attentional function in oncology outpatients receiving chemotherapy.

Review 3. Testosterone deficiency, insulin-resistant obesity and cognitive function.

4. Axon diameter and axonal transport: In vivo and in vitro effects of androgens.

Review 5. Androgens and the cerebrovasculature: modulation of vascular function during normal and pathophysiological conditions.

Review 6. Testosterone and the brain: from cognition to autism.

7. Genomic factors underlying sex differences in trauma-related disorders.

8. Decreased levels of γ-aminobutyric acid in temporal lobe of children with 47,XYY syndrome.

9. Sex differences in endogenous cortical network activity: spontaneously recurring Up/Down states.

10. The Effects of Gender Differences in Patients with Depression on Their Emotional Working Memory and Emotional Experience.