Jinjin Yu1, Yuan Wang, Ruofan Dong, Xiaoyan Huang, Suning Ding, Haifeng Qiu. 1. Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Suzhou University, Huihe Road No. 200, Binhu District, Wuxi 214062, People's Republic of China. wxsyyujj@gmail.com
Abstract
BACKGROUNDS: microRNA-218 was proved to be a tumor-suppressor microRNA in several cancers, but its status in cervical cancer patients has not been established. In this study, we investigated the expression of microRNA-218 in the sera from cervical cancer patients and its relationships with clinico-pathological characteristics. METHODS: The expression of microRNA-218 was detected in the sera of 90 cervical cancer patients and 50 normal age-matched women by quantitative real-time PCR. The clinical data were collected and analyzed by statistical software. RESULTS: In the cancer group, microRNA-218 was reduced significantly in the sera (P < 0.001). Moreover, decreased microRNA-218 was associated with later stages, cervical adenocarcinoma, and lymphatic node metastasis. CONCLUSIONS: microRNA-218 was deregulated in most cervical cancer patients and associated with tumor invasion.
BACKGROUNDS: microRNA-218 was proved to be a tumor-suppressor microRNA in several cancers, but its status in cervical cancerpatients has not been established. In this study, we investigated the expression of microRNA-218 in the sera from cervical cancerpatients and its relationships with clinico-pathological characteristics. METHODS: The expression of microRNA-218 was detected in the sera of 90 cervical cancerpatients and 50 normal age-matched women by quantitative real-time PCR. The clinical data were collected and analyzed by statistical software. RESULTS: In the cancer group, microRNA-218 was reduced significantly in the sera (P < 0.001). Moreover, decreased microRNA-218 was associated with later stages, cervical adenocarcinoma, and lymphatic node metastasis. CONCLUSIONS: microRNA-218 was deregulated in most cervical cancerpatients and associated with tumor invasion.
Authors: Nehad M Alajez; Michelle Lenarduzzi; Emma Ito; Angela B Y Hui; Wei Shi; Jeff Bruce; Shijun Yue; Shao H Huang; Wei Xu; John Waldron; Brian O'Sullivan; Fei-Fei Liu Journal: Cancer Res Date: 2011-03-08 Impact factor: 12.701
Authors: Jun Lu; Gad Getz; Eric A Miska; Ezequiel Alvarez-Saavedra; Justin Lamb; David Peck; Alejandro Sweet-Cordero; Benjamin L Ebert; Raymond H Mak; Adolfo A Ferrando; James R Downing; Tyler Jacks; H Robert Horvitz; Todd R Golub Journal: Nature Date: 2005-06-09 Impact factor: 49.962
Authors: Eric M Small; Lillian B Sutherland; Kartik N Rajagopalan; Shusheng Wang; Eric N Olson Journal: Circ Res Date: 2010-10-14 Impact factor: 17.367
Authors: Bei-Bei Tang; Shui-Yi Liu; Y U Zhan; Li-Qing Wei; Xiao-Lu Mao; Jin Wang; L I Li; Zhong-Xin Lu Journal: Exp Ther Med Date: 2015-04-28 Impact factor: 2.447