UNLABELLED: Sleep duration has been identified as risk factor for obesity already in children. Besides investigating the role of fat mass (FM), this study addressed the question whether endocrine mechanisms act as intermediates in the association between sleep duration and overweight/obesity. Within the framework of the IDEFICS study, the present research was conducted in 609 German resident children aged 2-9 years with information on fasting insulin, C-reactive protein and cortisol levels next to anthropometric measurements and parental questionnaires. Emphasising methodological aspects, an age-specific measure of sleep duration was derived to account for alteration in sleep duration during childhood/period of growth. Multivariate linear regression and quantile regression models confirmed an inverse relationship between sleep duration and measures of overweight/obesity. The estimate for the association of sleep duration and body mass index (BMI) was approximately halved after adjustment for FM, but remained significant. The strength of this association was also markedly attenuated when adjusting for insulin mainly for the upper BMI quantiles (Q80, β = -0.36 vs. β = -0.26; Q95, β = -0.87 vs. β = -0.47). Adjustment for cortisol and CrP did not yield this attenuation. CONCLUSION: The inverse relationship between sleep duration and BMI is mainly explained by the association between sleep duration and FM. Insulin may explain part of this association, in particular at the upper tail of the BMI distribution.
UNLABELLED: Sleep duration has been identified as risk factor for obesity already in children. Besides investigating the role of fat mass (FM), this study addressed the question whether endocrine mechanisms act as intermediates in the association between sleep duration and overweight/obesity. Within the framework of the IDEFICS study, the present research was conducted in 609 German resident children aged 2-9 years with information on fasting insulin, C-reactive protein and cortisol levels next to anthropometric measurements and parental questionnaires. Emphasising methodological aspects, an age-specific measure of sleep duration was derived to account for alteration in sleep duration during childhood/period of growth. Multivariate linear regression and quantile regression models confirmed an inverse relationship between sleep duration and measures of overweight/obesity. The estimate for the association of sleep duration and body mass index (BMI) was approximately halved after adjustment for FM, but remained significant. The strength of this association was also markedly attenuated when adjusting for insulin mainly for the upper BMI quantiles (Q80, β = -0.36 vs. β = -0.26; Q95, β = -0.87 vs. β = -0.47). Adjustment for cortisol and CrP did not yield this attenuation. CONCLUSION: The inverse relationship between sleep duration and BMI is mainly explained by the association between sleep duration and FM. Insulin may explain part of this association, in particular at the upper tail of the BMI distribution.
Authors: W Ahrens; K Bammann; A Siani; K Buchecker; S De Henauw; L Iacoviello; A Hebestreit; V Krogh; L Lissner; S Mårild; D Molnár; L A Moreno; Y P Pitsiladis; L Reisch; M Tornaritis; T Veidebaum; I Pigeot Journal: Int J Obes (Lond) Date: 2011-04 Impact factor: 5.095
Authors: Matthew W Gillman; Sheryl L Rifas-Shiman; Ken Kleinman; Emily Oken; Janet W Rich-Edwards; Elsie M Taveras Journal: Obesity (Silver Spring) Date: 2008-05-01 Impact factor: 5.002
Authors: Janis Baird; Catherine M Hill; Nicholas C Harvey; Sarah Crozier; Sian M Robinson; Keith M Godfrey; Cyrus Cooper; Hazel Inskip Journal: J Sleep Res Date: 2016-02-23 Impact factor: 3.981
Authors: Marie-Pierre St-Onge; Michael A Grandner; Devin Brown; Molly B Conroy; Girardin Jean-Louis; Michael Coons; Deepak L Bhatt Journal: Circulation Date: 2016-09-19 Impact factor: 29.690
Authors: Heidi B Iglayreger; Mark D Peterson; Dongmei Liu; Christine A Parker; Susan J Woolford; Bethany J Sallinen Gafka; Fauziya Hassan; Paul M Gordon Journal: J Pediatr Date: 2014-03-06 Impact factor: 4.406
Authors: Nicole G Altman; Bilgay Izci-Balserak; Elizabeth Schopfer; Nicholas Jackson; Pinyo Rattanaumpawan; Philip R Gehrman; Nirav P Patel; Michael A Grandner Journal: Sleep Med Date: 2012-11-08 Impact factor: 3.492
Authors: Claudia Börnhorst; Trudy M A Wijnhoven; Marie Kunešová; Agneta Yngve; Ana I Rito; Lauren Lissner; Vesselka Duleva; Ausra Petrauskiene; João Breda Journal: BMC Public Health Date: 2015-04-30 Impact factor: 3.295