Literature DB >> 2223581

Intrathecal administration of 131I radiolabelled monoclonal antibody as a treatment for neoplastic meningitis.

R P Moseley1, A G Davies, R B Richardson, M Zalutsky, S Carrell, J Fabre, N Slack, J Bullimore, B Pizer, V Papanastassiou.   

Abstract

Fifteen patients with neoplastic meningitis received a single intrathecal injection of between 11 and 60 mCi of a 131I radiolabelled monoclonal antibody (MoAb), chosen for its immunoreactivity to tumour. Major toxicity was manifest as nausea, vomiting and headache (7/15 patients), reversible bone marrow suppression (3/8 patients) and seizures (2/15 patients). Nine patients were evaluable for either a tumour or clinical response. Six of these demonstrated an event-free response that was maintained for periods of between 7 and 26 months.

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Year:  1990        PMID： 2223581      PMCID： PMC1971477          DOI： 10.1038/bjc.1990.345

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  30 in total

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Journal:  Immunol Rev       Date:  1982       Impact factor: 12.988

5.  Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture.

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6.  Covalent binding of methotrexate to immunoglobulins and the effect of antibody-linked drug on tumor growth in vivo.

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8.  Limitations to the killing of tumours using radiolabelled antibodies.

Authors:  A T Vaughan; P Anderson; P W Dykes; C E Chapman; A R Bradwell
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