| Literature DB >> 22232163 |
Sakiko Suzuki1, Hisaaki Yanai, Mayumi Kanagawa, Satoko Tamura, Yuzo Watanabe, Kyotaro Fuse, Seiki Baba, Gen-ichi Sampei, Gota Kawai.
Abstract
The crystal structure of PurL from Thermus thermophilus HB8 (TtPurL; TTHA1519) was determined in complex with an adenine nucleotide, PO(4)(3-) and Mg(2+) at 2.35 Å resolution. TtPurL consists of 29 α-helices and 28 β-strands, and one loop is disordered. TtPurL consists of four domains, A1, A2, B1 and B2, and the structures of the A1-B1 and A2-B2 domains were almost identical to each other. Although the sequence identity between TtPurL and PurL from Thermotoga maritima (TmPurL) is higher than that between TtPurL and the PurL domain of the large PurL from Salmonella typhimurium (StPurL), the secondary structure of TtPurL is much more similar to that of StPurL than to that of TmPurL.Entities:
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Year: 2011 PMID： 22232163 PMCID： PMC3253826 DOI： 10.1107/S1744309111048184
Source DB: PubMed Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun ISSN： 1744-3091