Literature DB >> 22231393

A new and convenient approach for the preparation of β-cyanoethyl protected trinucleotide phosphoramidites.

Matthäus Janczyk1, Bettina Appel, Danilo Springstubbe, Hans-Joachim Fritz, Sabine Müller.   

Abstract

Herein we report a convenient approach for the preparation of fully protected trinucleotide synthons to be used for the synthesis of gene libraries. The trinucleotide synthons bear β-cyanoethyl groups at the phosphate residues, and thus can be used in standard oligonucleotide synthesis without additional steps for deprotection and work-up.

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Year:  2012        PMID： 22231393     DOI： 10.1039/c2ob06934b

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  4 in total

1.  In vitro evolution of enzymes.

Authors:  Misha V Golynskiy; John C Haugner; Aleardo Morelli; Dana Morrone; Burckhard Seelig
Journal:  Methods Mol Biol       Date:  2013

2.  A Robust and Versatile Method of Combinatorial Chemical Synthesis of Gene Libraries via Hierarchical Assembly of Partially Randomized Modules.

Authors:  Blagovesta Popova; Steffen Schubert; Ingo Bulla; Daniela Buchwald; Wilfried Kramer
Journal:  PLoS One       Date:  2015-09-10       Impact factor: 3.240

Review 3.  Preparation of trinucleotide phosphoramidites as synthons for the synthesis of gene libraries.

Authors:  Ruth Suchsland; Bettina Appel; Sabine Müller
Journal:  Beilstein J Org Chem       Date:  2018-02-13       Impact factor: 2.883

4.  Synthesis of fully protected trinucleotide building blocks on a disulphide-linked soluble support.

Authors:  Ruth Suchsland; Bettina Appel; Pasi Virta; Sabine Müller
Journal:  RSC Adv       Date:  2021-01-20       Impact factor: 3.361
  4 in total

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