Literature DB >> 22231117

Transcription and splicing: when the twain meet.

Yehuda Brody1, Yaron Shav-Tal.   

Abstract

Splicing can occur co-transcriptionally. What happens when the splicing reaction lags after the completed transcriptional process? We found that elongation rates are independent of ongoing splicing on the examined genes and suggest that when transcription has completed but splicing has not, the splicing machinery is retained at the site of transcription, independently of the polymerase.

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Year:  2011        PMID： 22231117      PMCID： PMC3265778          DOI： 10.4161/trns.2.5.17273

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  47 in total

1.  A slow RNA polymerase II affects alternative splicing in vivo.

Authors:  Manuel de la Mata; Claudio R Alonso; Sebastián Kadener; Juan P Fededa; Matías Blaustein; Federico Pelisch; Paula Cramer; David Bentley; Alberto R Kornblihtt
Journal:  Mol Cell       Date:  2003-08       Impact factor: 17.970

2.  The life of an mRNA in space and time.

Authors:  Ya'ara Ben-Ari; Yehuda Brody; Noa Kinor; Amir Mor; Toshiro Tsukamoto; David L Spector; Robert H Singer; Yaron Shav-Tal
Journal:  J Cell Sci       Date:  2010-04-27       Impact factor: 5.285

Review 3.  More than a splicing code: integrating the role of RNA, chromatin and non-coding RNA in alternative splicing regulation.

Authors:  Reini F Luco; Tom Misteli
Journal:  Curr Opin Genet Dev       Date:  2011-04-15       Impact factor: 5.578

4.  The Carboxyl-terminal Domain of RNA Polymerase II Is Not Sufficient to Enhance the Efficiency of Pre-mRNA Capping or Splicing in the Context of a Different Polymerase.

Authors:  Barbara J Natalizio; Nicole D Robson-Dixon; Mariano A Garcia-Blanco
Journal:  J Biol Chem       Date:  2009-01-28       Impact factor: 5.157

5.  RNP particles at splice junction sequences on Drosophila chorion transcripts.

Authors:  Y N Osheim; O L Miller; A L Beyer
Journal:  Cell       Date:  1985-11       Impact factor: 41.582

6.  Measuring the kinetics of mRNA transcription in single living cells.

Authors:  Yehuda Brody; Yaron Shav-Tal
Journal:  J Vis Exp       Date:  2011-08-25       Impact factor: 1.355

7.  A wave of nascent transcription on activated human genes.

Authors:  Youichiro Wada; Yoshihiro Ohta; Meng Xu; Shuichi Tsutsumi; Takashi Minami; Kenji Inoue; Daisuke Komura; Jun'ichi Kitakami; Nobuhiko Oshida; Argyris Papantonis; Akashi Izumi; Mika Kobayashi; Hiroko Meguro; Yasuharu Kanki; Imari Mimura; Kazuki Yamamoto; Chikage Mataki; Takao Hamakubo; Katsuhiko Shirahige; Hiroyuki Aburatani; Hiroshi Kimura; Tatsuhiko Kodama; Peter R Cook; Sigeo Ihara
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-13       Impact factor: 11.205

8.  Splicing and transcription-associated proteins PSF and p54nrb/nonO bind to the RNA polymerase II CTD.

Authors:  Andrew Emili; Michael Shales; Susan McCracken; Weijun Xie; Philip W Tucker; Ryuji Kobayashi; Benjamin J Blencowe; C James Ingles
Journal:  RNA       Date:  2002-09       Impact factor: 4.942

9.  The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing.

Authors:  Yehuda Brody; Noa Neufeld; Nicole Bieberstein; Sebastien Z Causse; Eva-Maria Böhnlein; Karla M Neugebauer; Xavier Darzacq; Yaron Shav-Tal
Journal:  PLoS Biol       Date:  2011-01-11       Impact factor: 8.029

10.  Splicing-dependent RNA polymerase pausing in yeast.

Authors:  Ross D Alexander; Steven A Innocente; J David Barrass; Jean D Beggs
Journal:  Mol Cell       Date:  2010-11-24       Impact factor: 19.328
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  4 in total

Review 1.  Single-Cell and Single-Molecule Analysis of Gene Expression Regulation.

Authors:  Maria Vera; Jeetayu Biswas; Adrien Senecal; Robert H Singer; Hye Yoon Park
Journal:  Annu Rev Genet       Date:  2016-11-23       Impact factor: 16.830

2.  Identification by high-throughput imaging of the histone methyltransferase EHMT2 as an epigenetic regulator of VEGFA alternative splicing.

Authors:  Maayan Salton; Ty C Voss; Tom Misteli
Journal:  Nucleic Acids Res       Date:  2014-11-20       Impact factor: 16.971

3.  Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2.

Authors:  Linlin Hou; Yuanjie Wei; Yingying Lin; Xiwei Wang; Yiwei Lai; Menghui Yin; Yanpu Chen; Xiangpeng Guo; Senbin Wu; Yindi Zhu; Jie Yuan; Muqddas Tariq; Na Li; Hao Sun; Huating Wang; Xiaofei Zhang; Jiekai Chen; Xichen Bao; Ralf Jauch
Journal:  Nucleic Acids Res       Date:  2020-04-17       Impact factor: 16.971

4.  RSR-2, the Caenorhabditis elegans ortholog of human spliceosomal component SRm300/SRRM2, regulates development by influencing the transcriptional machinery.

Authors:  Laura Fontrodona; Montserrat Porta-de-la-Riva; Tomás Morán; Wei Niu; Mònica Díaz; David Aristizábal-Corrales; Alberto Villanueva; Simó Schwartz; Valerie Reinke; Julián Cerón
Journal:  PLoS Genet       Date:  2013-06-06       Impact factor: 5.917
  4 in total

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