Literature DB >> 22229046

Epithelial-mesenchymal transition in pulmonary carcinosarcoma: case report and literature review.

Vibha T Thomas1, Stacy Hinson, Kartik Konduri.   

Abstract

Pulmonary carcinosarcoma is a rare and aggressive neoplasm that has both epithelial and mesenchymal components. We report on a 63-year-old woman who was found to have a right upper-lobe pulmonary carcinosarcoma with metastases to the liver and gastric fundus. There are currently no published guidelines on the treatment of pulmonary sarcomatoid carcinomas. However, with our expanding knowledge of cancer metastasis, cases of carcinosarcoma illustrate our current understanding of epithelial-mesenchymal transition in action. Here, we discuss the development and treatment of these biphasic tumors and the possible role of epithelial-mesenchymal transition.

Entities:  

Keywords:  carcinosarcoma; epithelial–mesenchymal transition; lung neoplasms

Year:  2012        PMID： 22229046      PMCID： PMC3244200          DOI： 10.1177/1758834011421949

Source DB:  PubMed          Journal:  Ther Adv Med Oncol        ISSN： 1758-8340            Impact factor:   8.168


  31 in total

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Journal:  Cell       Date:  2009-11-25       Impact factor: 41.582

2.  Pulmonary blastoma: report of five cases and identification of clinical features suggestive of the disease.

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Journal:  Eur J Cardiothorac Surg       Date:  2002-11       Impact factor: 4.191

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Review 4.  Carcinosarcomas of the lung: a clinicopathologic study of 66 patients.

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Journal:  Am J Surg Pathol       Date:  1999-12       Impact factor: 6.394

Review 5.  No one-way street: cross-talk between e-cadherin and receptor tyrosine kinase (RTK) signaling: a mechanism to regulate RTK activity.

Authors:  Claudia D Andl; Anil K Rustgi
Journal:  Cancer Biol Ther       Date:  2005-01-15       Impact factor: 4.742

6.  Lung carcinosarcoma.

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Journal:  Clin Transl Oncol       Date:  2010-04       Impact factor: 3.405

7.  Pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements: a clinicopathologic and immunohistochemical study of 75 cases.

Authors:  Giulio Rossi; Alberto Cavazza; Nathalie Sturm; Mario Migaldi; Nicola Facciolongo; Lucia Longo; Antonio Maiorana; Elisabeth Brambilla
Journal:  Am J Surg Pathol       Date:  2003-03       Impact factor: 6.394

8.  E-cadherin binding modulates EGF receptor activation.

Authors:  Mary Fedor-Chaiken; Patrick W Hein; Jane C Stewart; Robert Brackenbury; Michael S Kinch
Journal:  Cell Commun Adhes       Date:  2003 Mar-Apr

9.  Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression?

Authors:  Eva A Turley; Mandana Veiseh; Derek C Radisky; Mina J Bissell
Journal:  Nat Clin Pract Oncol       Date:  2008-03-18

Review 10.  Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe.

Authors:  Michael W Klymkowsky; Pierre Savagner
Journal:  Am J Pathol       Date:  2009-03-26       Impact factor: 4.307
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  7 in total

1.  Synchronous primary lung sarcomatous carcinoma and lung squamous cell carcinoma: a case report.

Authors:  Maoyuan Zhao; Qiuyang Jing; Zhouguang Hui
Journal:  Int J Clin Exp Pathol       Date:  2020-03-01

2.  Giant cell carcinoma of the lung presenting as an isolated cyst containing air: A case report.

Authors:  Meifang Wang; Yuquan Liu; Xin Qian; Dan Li; Hui You; Na Wei; Yijun Tang
Journal:  Medicine (Baltimore)       Date:  2019-05       Impact factor: 1.817

3.  Pten and p53 Loss in the Mouse Lung Causes Adenocarcinoma and Sarcomatoid Carcinoma.

Authors:  Sara Lázaro; Corina Lorz; Ana Belén Enguita; Iván Seller; Jesús M Paramio; Mirentxu Santos
Journal:  Cancers (Basel)       Date:  2022-07-28       Impact factor: 6.575

4.  Pulmonary Carcinosarcoma: A Rare Disease With Challenging Diagnosis and Treatment.

Authors:  Erinie Mekheal; Ashima Kapoor; Sherif Roman; Nader Mekheal; Christopher Millet; Marina Mekheal; Michael Maroules
Journal:  Cureus       Date:  2022-07-15

5.  Imaging, Histopathologic, and Treatment Nuances of Pulmonary Carcinosarcoma.

Authors:  Tyler Gleason; Michael Haas; Brian H Le
Journal:  Case Rep Radiol       Date:  2017-09-17

6.  Overexpression of p53R2 is associated with poor prognosis in lung sarcomatoid carcinoma.

Authors:  Jiewei Chen; Yongbo Xiao; Xiaoyan Cai; Jun Liu; Keming Chen; Xinke Zhang
Journal:  BMC Cancer       Date:  2017-12-15       Impact factor: 4.430

7.  Gingival metastasis of a mediastinal pulmonary sarcomatoid carcinoma: a case report.

Authors:  Zhonghua Qin; Bin Huang; Guiping Yu; Yongqiang Zheng; Ke Zhao
Journal:  J Cardiothorac Surg       Date:  2019-09-09       Impact factor: 1.637
  7 in total

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