Jee-Young Yeon1, Hyun-Sook Kim, Mi-Kyung Sung. 1. Department of Food and Nutrition, Sookmyung Women's University, 100 Chungpa-ro 47-gil, Yongsan-gu, Seoul 140–742, Republic of Korea. yonwl@yahoo.co.kr
Abstract
OBJECTIVE: This study was performed to evaluate the effects of high vegetable-fruit (high-VF) and low vegetable-fruit (low-VF) diet on surrogate biomarkers of adiposity-related metabolic disturbances. METHODS: Overweight women (n=22, 19-29 years) participated in the study between July and August, 2007 in Seoul, Korea. The intervention consisted of either high-VF diet (12 servings of VF/day) or low-VF diet (2 servings of VF/day). Plasma concentration of carotenoids and biomarkers of inflammation and oxidative stress were determined before and after each intervention period. RESULTS: Study results indicated that body fat content is positively correlated with plasma interleukin (IL)-6, C-reactive protein (CRP), and leptin concentrations at baseline. Oxidative DNA damage and lipopolysaccharide (LPS)-activated production of IL-1β and IL-6 in peripheral blood mononuclear cells (PBMCs) were decreased with high-VF diet while low-VF diet increased those markers. Changes in the concentration of plasma total carotenoid and β-carotene were inversely correlated with change in plasma IL-1β concentration. Differences in IL-β production in LPS-activated PBMCs were inversely correlated with changes in plasma concentration of lutein-zeaxanthin. Also, changes in plasma total carotenoid and lycopene concentration were inversely correlated with the changes in IL-6 production in LPS-activated PBMCs. CONCLUSION: Daily intake of vegetables and fruits can modify adiposity-related metabolic disturbances.
OBJECTIVE: This study was performed to evaluate the effects of high vegetable-fruit (high-VF) and low vegetable-fruit (low-VF) diet on surrogate biomarkers of adiposity-related metabolic disturbances. METHODS: Overweight women (n=22, 19-29 years) participated in the study between July and August, 2007 in Seoul, Korea. The intervention consisted of either high-VF diet (12 servings of VF/day) or low-VF diet (2 servings of VF/day). Plasma concentration of carotenoids and biomarkers of inflammation and oxidative stress were determined before and after each intervention period. RESULTS: Study results indicated that body fat content is positively correlated with plasma interleukin (IL)-6, C-reactive protein (CRP), and leptin concentrations at baseline. Oxidative DNA damage and lipopolysaccharide (LPS)-activated production of IL-1β and IL-6 in peripheral blood mononuclear cells (PBMCs) were decreased with high-VF diet while low-VF diet increased those markers. Changes in the concentration of plasma total carotenoid and β-carotene were inversely correlated with change in plasma IL-1β concentration. Differences in IL-β production in LPS-activated PBMCs were inversely correlated with changes in plasma concentration of lutein-zeaxanthin. Also, changes in plasma total carotenoid and lycopene concentration were inversely correlated with the changes in IL-6 production in LPS-activated PBMCs. CONCLUSION: Daily intake of vegetables and fruits can modify adiposity-related metabolic disturbances.
Authors: Faith I Umoh; Ikuko Kato; Jianwei Ren; Phillip L Wachowiak; Mack T Ruffin; D Kim Turgeon; Ananda Sen; Dean E Brenner; Zora Djuric Journal: Eur J Nutr Date: 2015-04-24 Impact factor: 5.614
Authors: Shilpa N Bhupathiraju; Nicole M Wedick; An Pan; JoAnn E Manson; Kathyrn M Rexrode; Walter C Willett; Eric B Rimm; Frank B Hu Journal: Am J Clin Nutr Date: 2013-10-02 Impact factor: 7.045