OBJECTIVES: Gangliosides are structural and functional glycosphingolipids, considered to have important roles in neuronal development in fetal and neonatal development and in memory formation. In this report, we have investigated the ability of bovine milk-derived gangliosides GM3 and GD3 to cross the human placenta. STUDY DESIGN: We have employed the ex-vivo model of dually-perfused isolated human placental lobules. RESULTS: There was significant uptake of both GD3 and GM3 from the maternal perfusate. There was significant increase of GM3 in the fetal side and a non-statistically significant trend for GD3 to increase on the fetal side. CONCLUSIONS: Hence an apparent preference for GM3 release into fetal circulation. We suggest that gangliosides consumed by the mother enter her circulation, can be transferred across the placenta and may be available to the developing fetus for building neural connections. Copyright Â
OBJECTIVES:Gangliosides are structural and functional glycosphingolipids, considered to have important roles in neuronal development in fetal and neonatal development and in memory formation. In this report, we have investigated the ability of bovine milk-derived gangliosidesGM3 and GD3 to cross the human placenta. STUDY DESIGN: We have employed the ex-vivo model of dually-perfused isolated human placental lobules. RESULTS: There was significant uptake of both GD3 and GM3 from the maternal perfusate. There was significant increase of GM3 in the fetal side and a non-statistically significant trend for GD3 to increase on the fetal side. CONCLUSIONS: Hence an apparent preference for GM3 release into fetal circulation. We suggest that gangliosides consumed by the mother enter her circulation, can be transferred across the placenta and may be available to the developing fetus for building neural connections. Copyright Â
Authors: Denggao Yao; Rhona McGonigal; Jennifer A Barrie; Joanna Cappell; Madeleine E Cunningham; Gavin R Meehan; Simon N Fewou; Julia M Edgar; Edward Rowan; Yuhsuke Ohmi; Keiko Furukawa; Koichi Furukawa; Peter J Brophy; Hugh J Willison Journal: J Neurosci Date: 2014-01-15 Impact factor: 6.167
Authors: Xiyao Liu; Huijia Fu; Li Wen; Fangyu Zhu; Yue Wu; Zhi Chen; Richard Saffery; Chang Chen; Hongbo Qi; Chao Tong; Philip N Baker; Mark D Kilby Journal: Front Mol Biosci Date: 2022-04-08
Authors: Benjamin B Albert; José G B Derraik; Yin-Yin Xia; Tom Norris; Ting Zhang; Ting-Li Han; Chen Chang; Angela Rowan; Sophie Gallier; Renato T Souza; Judith J Hammond; Wei Zhou; Hua Zhang; Hong-Bo Qi; Philip N Baker Journal: PLoS One Date: 2021-02-24 Impact factor: 3.240