BACKGROUND: Left atrial (LA) volume index (LAVI) has been considered a stable indicator of diastolic dysfunction and an independent predictor of mortality in patients with end-stage renal disease. To date, however, little is known about the relationship between LA enlargement and the changes in residual renal function (RRF). METHODS: This study was undertaken to investigate the association between LA enlargement and the decline in RRF in 121 incident peritoneal dialysis patients. Within 2 months after the initiation of peritoneal dialysis, LA enlargement was determined by echocardiography and RRF by 24-hour urine collection. Subsequently, RRF was measured every 6 months. RESULTS: The rates of decline in RRF were significantly greater in patients with LA enlargement (LAVI > 32 mL/m(2)) compared with those without LA enlargement (-0.17 ± 0.18 vs -0.07 ± 0.16 mL/min/month/1.73 m(2), P = .002). In a linear mixed model, there was a significant difference in the rates of RRF decline over time between patients with and without LA enlargement (P < .001). Pearson's correlation analysis revealed that there were significant inverse correlations between the rates of the decline in RRF and LAVI (r = -0.22, P = .018). In multiple linear regression analysis adjusted for other risk factors, LAVI was found to be an independent determinant of the rates of decline in RRF (β = -0.026, P = .018). CONCLUSIONS: This study shows that a higher LAVI is independently associated with a more rapid decline in RRF in patients with end-stage renal disease on peritoneal dialysis.
BACKGROUND: Left atrial (LA) volume index (LAVI) has been considered a stable indicator of diastolic dysfunction and an independent predictor of mortality in patients with end-stage renal disease. To date, however, little is known about the relationship between LA enlargement and the changes in residual renal function (RRF). METHODS: This study was undertaken to investigate the association between LA enlargement and the decline in RRF in 121 incident peritoneal dialysis patients. Within 2 months after the initiation of peritoneal dialysis, LA enlargement was determined by echocardiography and RRF by 24-hour urine collection. Subsequently, RRF was measured every 6 months. RESULTS: The rates of decline in RRF were significantly greater in patients with LA enlargement (LAVI > 32 mL/m(2)) compared with those without LA enlargement (-0.17 ± 0.18 vs -0.07 ± 0.16 mL/min/month/1.73 m(2), P = .002). In a linear mixed model, there was a significant difference in the rates of RRF decline over time between patients with and without LA enlargement (P < .001). Pearson's correlation analysis revealed that there were significant inverse correlations between the rates of the decline in RRF and LAVI (r = -0.22, P = .018). In multiple linear regression analysis adjusted for other risk factors, LAVI was found to be an independent determinant of the rates of decline in RRF (β = -0.026, P = .018). CONCLUSIONS: This study shows that a higher LAVI is independently associated with a more rapid decline in RRF in patients with end-stage renal disease on peritoneal dialysis.
Authors: Hyang Mo Koo; Fa Mee Doh; Chan Ho Kim; Mi Jung Lee; Eun Jin Kim; Jae Hyun Han; Ji Suk Han; Dong-Ryeol Ryu; Hyung Jung Oh; Jung Tak Park; Seung Hyeok Han; Tae-Hyun Yoo; Shin-Wook Kang Journal: Medicine (Baltimore) Date: 2015-02 Impact factor: 1.889
Authors: Jae Hyun Han; Ji Suk Han; Eun Jin Kim; Fa Mee Doh; Hyang Mo Koo; Chan Ho Kim; Mi Jung Lee; Hyung Jung Oh; Jung Tak Park; Seung Hyeok Han; Dong-Ryeol Ryu; Tae-Hyun Yoo; Shin-Wook Kang Journal: PLoS One Date: 2015-03-04 Impact factor: 3.240
Authors: Sara Mahdavi; Kibar Yared; George Wu; Billy Omar; Dinesh Savundra; Gordon Nagai; Edgar Hockmann; Anton Svendrovski; Antonio Bellasi; Paul Tam; Tabo Sikaneta Journal: Sci Rep Date: 2019-12-05 Impact factor: 4.379