Literature DB >> 2977537

Cilofungin (LY121019) inhibits Candida albicans (1-3)-beta-D-glucan synthase activity.

C S Taft1, T Stark, C P Selitrennikoff.   

Abstract

Cilofungin (LY121019) inhibited Candida albicans growth and activity of (1-3)-beta-glucan synthase, for which it was a noncompetitive inhibitor with a Ki-app of 2.5 microM. Cilofungin had no effect on chitin synthase activity. Based on these and other data, it seems likely that cilofungin inhibits fungal growth by inhibiting (1-3)-beta-glucan synthase activity.

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Year:  1988        PMID： 2977537      PMCID： PMC176043          DOI： 10.1128/AAC.32.12.1901

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.

Authors:  W W CLELAND
Journal:  Biochim Biophys Acta       Date:  1963-01-08

2.  Chitin synthase activity from the slime variant of Neurospora crassa.

Authors:  C P Selitrennikoff
Journal:  Biochim Biophys Acta       Date:  1979-12-07

3.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

4.  Changes in the plasma membrane of regenerating protoplasts of Candida albicans as revealed by freeze-fracture electron microscopy.

Authors:  F Miragall; H Rico; R Sentandreu
Journal:  J Gen Microbiol       Date:  1986-10

5.  LY121019 inhibits Neurospora crassa growth and (1-3)-beta-D-glucan synthase.

Authors:  C S Taft; C P Selitrennikoff
Journal:  J Antibiot (Tokyo)       Date:  1988-05       Impact factor: 2.649

6.  In vitro and in vivo anti-Candida activity and toxicology of LY121019.

Authors:  R S Gordee; D J Zeckner; L F Ellis; A L Thakkar; L C Howard
Journal:  J Antibiot (Tokyo)       Date:  1984-09       Impact factor: 2.649

7.  (1,3)-beta-D-Glucan synthase from budding and filamentous cultures of the dimorphic fungus Candida albicans.

Authors:  P A Orlean
Journal:  Eur J Biochem       Date:  1982-10
  7 in total
  32 in total

1.  W-1 solubilization and kinetics of inhibition by cilofungin of Candida albicans (1,3)-beta-D-glucan synthase.

Authors:  J Tang; T R Parr
Journal:  Antimicrob Agents Chemother       Date:  1991-01       Impact factor: 5.191

2.  Efficacy of cilofungin therapy administered by continuous intravenous infusion for experimental disseminated candidiasis in rabbits.

Authors:  M S Rouse; B M Tallan; J M Steckelberg; N K Henry; W R Wilson
Journal:  Antimicrob Agents Chemother       Date:  1992-01       Impact factor: 5.191

Review 3.  Antifungal peptides: novel therapeutic compounds against emerging pathogens.

Authors:  A J De Lucca; T J Walsh
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

4.  Treatment of Pneumocystis carinii pneumonia with 1,3-beta-glucan synthesis inhibitors.

Authors:  D M Schmatz; M A Romancheck; L A Pittarelli; R E Schwartz; R A Fromtling; K H Nollstadt; F L Vanmiddlesworth; K E Wilson; M J Turner
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

5.  Photoaffinity analog of the semisynthetic echinocandin LY303366: identification of echinocandin targets in Candida albicans.

Authors:  J A Radding; S A Heidler; W W Turner
Journal:  Antimicrob Agents Chemother       Date:  1998-05       Impact factor: 5.191

6.  Comparative efficacies of cilofungin (Ly121019) and amphotericin B against disseminated Candida albicans infection in normal and granulocytopenic mice.

Authors:  N Khardori; H Nguyen; L C Stephens; L Kalvakuntla; B Rosenbaum; G P Bodey
Journal:  Antimicrob Agents Chemother       Date:  1993-04       Impact factor: 5.191

7.  CRS-MIS in Candida glabrata: sphingolipids modulate echinocandin-Fks interaction.

Authors:  Kelley R Healey; Santosh K Katiyar; Shriya Raj; Thomas D Edlind
Journal:  Mol Microbiol       Date:  2012-08-22       Impact factor: 3.501

8.  Efficacy of cilofungin alone and in combination with amphotericin B in a murine model of disseminated aspergillosis.

Authors:  D W Denning; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  1991-07       Impact factor: 5.191

9.  Anti-Candida and mode of action of two newly synthesized polymers: a modified poly (methylmethacrylate-co-vinylbenzoylchloride) and a modified linear poly (chloroethylvinylether-co-vinylbenzoylchloride) with special reference to Candida albicans and Candida tropicalis.

Authors:  Yehia A G Mahmoud; Magda M Aly
Journal:  Mycopathologia       Date:  2004-02       Impact factor: 2.574

10.  Nikkomycin Z supersensitivity of an echinocandin-resistant mutant of Saccharomyces cerevisiae.

Authors:  M el-Sherbeini; J A Clemas
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191
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