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Literature DB >> 22215804

A firm grip does not always pay off: a new Phact(r) 4 integrin signaling.

Abstract

β1 integrin signaling plays crucial roles in enteric nervous system development. Zhang and colleagues (pp. 69-81) discovered that phosphatase and actin regulator 4 (Phactr4) antagonizes β1 integrin signaling through protein phosphatase 1 (PP1) in focal adhesions of enteric neural crest cells (ENCCs). Loss of Phactr4-PP1 interaction leads to increased β1 integrin signaling, loss of collective and directional migration, and hindgut hypogangaliosis, indicating that the right adjustment of β1 integrin signaling is required for the normal migration and organization of ENCCs.

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Year: 2012 PMID： 22215804 PMCID： PMC3258960 DOI： 10.1101/gad.184192.111

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

38 in total

1. Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype.

Authors: Marie A Breau; Thomas Pietri; Olivier Eder; Martine Blanche; Cord Brakebusch; Reinhardt Fässler; Jean P Thiery; Sylvie Dufour
Journal: Development Date: 2006-03-29 Impact factor: 6.868

2. Behavior of enteric neural crest-derived cells varies with respect to the migratory wavefront.

Authors: Noah R Druckenbrod; Miles L Epstein
Journal: Dev Dyn Date: 2007-01 Impact factor: 3.780

Review 3. Studying the genetics of Hirschsprung's disease: unraveling an oligogenic disorder.

Authors: A S Brooks; B A Oostra; R M W Hofstra
Journal: Clin Genet Date: 2005-01 Impact factor: 4.438

4. Consequences of lack of beta 1 integrin gene expression in mice.

Authors: R Fässler; M Meyer
Journal: Genes Dev Date: 1995-08-01 Impact factor: 11.361

5. GDNF and ET-3 differentially modulate the numbers of avian enteric neural crest cells and enteric neurons in vitro.

Authors: C J Hearn; M Murphy; D Newgreen
Journal: Dev Biol Date: 1998-05-01 Impact factor: 3.582

Review 6. Integrin ligands at a glance.

Authors: Jonathan D Humphries; Adam Byron; Martin J Humphries
Journal: J Cell Sci Date: 2006-10-01 Impact factor: 5.285

A firm grip does not always pay off: a new Phact(r) 4 integrin signaling.

1. Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype.

2. Behavior of enteric neural crest-derived cells varies with respect to the migratory wavefront.

Review 3. Studying the genetics of Hirschsprung's disease: unraveling an oligogenic disorder.

4. Consequences of lack of beta 1 integrin gene expression in mice.

5. GDNF and ET-3 differentially modulate the numbers of avian enteric neural crest cells and enteric neurons in vitro.

Review 6. Integrin ligands at a glance.

7. The pattern of neural crest advance in the cecum and colon.

Review 8. ILK, PINCH and parvin: the tIPP of integrin signalling.

9. Dynamics of neural crest-derived cell migration in the embryonic mouse gut.

Review 10. Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies.

Review 1. Functions and therapeutic potential of protein phosphatase 1: Insights from mouse genetics.