Literature DB >> 16493410

ILK, PINCH and parvin: the tIPP of integrin signalling.

Kyle R Legate1, Eloi Montañez, Oliver Kudlacek, Reinhard Fässler.   

Abstract

The ternary complex of integrin-linked kinase (ILK), PINCH and parvin functions as a signalling platform for integrins by interfacing with the actin cytoskeleton and many diverse signalling pathways. All these proteins have synergistic functions at focal adhesions, but recent work has indicated that these proteins might also have separate roles within a cell. They function as regulators of gene transcription or cell-cell adhesion.

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Year:  2006        PMID： 16493410     DOI： 10.1038/nrm1789

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  284 in total

1.  Effect of uraemia on endothelial cell damage is mediated by the integrin linked kinase pathway.

Authors:  Andrea García-Jérez; Alicia Luengo; Julia Carracedo; Rafael Ramírez-Chamond; Diego Rodriguez-Puyol; Manuel Rodriguez-Puyol; Laura Calleros
Journal:  J Physiol       Date:  2014-12-18       Impact factor: 5.182

2.  PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha.

Authors:  Iris Eke; Ulrike Koch; Stephanie Hehlgans; Veit Sandfort; Fabio Stanchi; Daniel Zips; Michael Baumann; Anna Shevchenko; Christian Pilarsky; Michael Haase; Gustavo B Baretton; Véronique Calleja; Banafshé Larijani; Reinhard Fässler; Nils Cordes
Journal:  J Clin Invest       Date:  2010-06-07       Impact factor: 14.808

Review 3.  Cellular and molecular mechanisms of renal fibrosis.

Authors:  Youhua Liu
Journal:  Nat Rev Nephrol       Date:  2011-10-18       Impact factor: 28.314

4.  Ancient origin of the integrin-mediated adhesion and signaling machinery.

Authors:  Arnau Sebé-Pedrós; Andrew J Roger; Franz B Lang; Nicole King; Iñaki Ruiz-Trillo
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-17       Impact factor: 11.205

Review 5.  Recent advances in the understanding of the molecular mechanisms regulating platelet integrin αIIbβ3 activation.

Authors:  Lanlan Tao; Yue Zhang; Xiaodong Xi; Nelly Kieffer
Journal:  Protein Cell       Date:  2010-07-29       Impact factor: 14.870

6.  Characterization of nuclear localization signal in the N terminus of integrin-linked kinase-associated phosphatase (ILKAP) and its essential role in the down-regulation of RSK2 protein signaling.

Authors:  Wang Zhou; Hao Cao; Xinghai Yang; Kan Cong; Wei Wang; Tianrui Chen; Huabin Yin; Zhipeng Wu; Xiaopan Cai; Tielong Liu; Jianru Xiao
Journal:  J Biol Chem       Date:  2013-01-17       Impact factor: 5.157

7.  The structural basis of integrin-linked kinase-PINCH interactions.

Authors:  Brian P Chiswell; Rong Zhang; James W Murphy; Titus J Boggon; David A Calderwood
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-12       Impact factor: 11.205

8.  The mechanism of kindlin-mediated activation of integrin αIIbβ3.

Authors:  Feng Ye; Brian G Petrich; Praju Anekal; Craig T Lefort; Ana Kasirer-Friede; Sanford J Shattil; Raphael Ruppert; Markus Moser; Reinhard Fässler; Mark H Ginsberg
Journal:  Curr Biol       Date:  2013-11-07       Impact factor: 10.834

9.  Changes in PINCH levels in the CSF of HIV+ individuals correlate with hpTau and CD4 count.

Authors:  Radhika Adiga; Ahmet Y Ozdemir; Alexandra Carides; Melissa Wasilewski; William Yen; Pallavi Chitturi; Ronald Ellis; Dianne Langford
Journal:  J Neurovirol       Date:  2014-05-10       Impact factor: 2.643

10.  Drosophila importin-7 functions upstream of the Elmo signaling module to mediate the formation and stability of muscle attachments.

Authors:  Ze Cindy Liu; Nadia Odell; Erika R Geisbrecht
Journal:  J Cell Sci       Date:  2013-09-17       Impact factor: 5.285
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