Literature DB >> 22215066

Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate.

Sinem Tuncel1, Jérémie Fournier-dit-Chabert, Florian Albrieux, Vefa Ahsen, Sylvie Ducki, Fabienne Dumoulin.   

Abstract

A phthalocyanine-chalcone conjugate has been designed to combine the vascular disrupting effect of chalcones with the photodynamic effect of phthalocyanines. This potential dual photodynamic and antiangiogenic agent was obtained by the condensation of a tetrahydroxylated non-peripherally substituted Zn(ii) phthalocyanine with an amino chalcone converted into the corresponding activated isocyanate. The conjugate was fully characterized.

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Year:  2012        PMID： 22215066     DOI： 10.1039/c2ob06809e

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  4 in total

Review 1.  Chalcone: A Privileged Structure in Medicinal Chemistry.

Authors:  Chunlin Zhuang; Wen Zhang; Chunquan Sheng; Wannian Zhang; Chengguo Xing; Zhenyuan Miao
Journal:  Chem Rev       Date:  2017-05-10       Impact factor: 60.622

2.  Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors.

Authors:  Lívia B Salum; Wanessa F Altei; Louise D Chiaradia; Marlon N S Cordeiro; Rafael R Canevarolo; Carolina P S Melo; Evelyn Winter; Bruno Mattei; Hikmat N Daghestani; Maria Cláudia Santos-Silva; Tânia B Creczynski-Pasa; Rosendo A Yunes; José A Yunes; Adriano D Andricopulo; Billy W Day; Ricardo J Nunes; Andreas Vogt
Journal:  Eur J Med Chem       Date:  2013-03-06       Impact factor: 6.514

3.  Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents.

Authors:  Jiabing Wang; Lili Huang; Chanchan Cheng; Ge Li; Jingwen Xie; Mengya Shen; Qian Chen; Wulan Li; Wenfei He; Peihong Qiu; Jianzhang Wu
Journal:  Acta Pharm Sin B       Date:  2019-01-07       Impact factor: 14.903

4.  Synthesis and electrochemical properties of copper(II), manganese(III) phthalocyanines bearing chalcone groups at peripheral or nonperipheral positions.

Authors:  Hüseyin BaŞ; Nuran Kahrİman; Zekeriya BiyiklioĞlu
Journal:  Turk J Chem       Date:  2020-12-16       Impact factor: 1.239
  4 in total

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