Literature DB >> 22212522

Creation of an artificial metalloprotein with a Hoveyda-Grubbs catalyst moiety through the intrinsic inhibition mechanism of α-chymotrypsin.

Takashi Matsuo1, Chie Imai, Takefumi Yoshida, Takashi Saito, Takashi Hayashi, Shun Hirota.   

Abstract

An L-phenylalanyl chloromethylketone-based inhibitor equipped with a Hoveyda-Grubbs catalyst moiety was regioselectively incorporated into the cleft of α-chymotrypsin through the intrinsic inhibition mechanism of the protein to construct an artificial organometallic protein. This journal is © The Royal Society of Chemistry 2012

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Year:  2012        PMID： 22212522     DOI： 10.1039/c2cc16898g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Designing functional metalloproteins: from structural to catalytic metal sites.

Authors:  Melissa L Zastrow; Vincent L Pecoraro
Journal:  Coord Chem Rev       Date:  2013-09       Impact factor: 22.315

Review 2.  Design of artificial metalloproteins/metalloenzymes by tuning noncovalent interactions.

Authors:  Shun Hirota; Ying-Wu Lin
Journal:  J Biol Inorg Chem       Date:  2017-12-07       Impact factor: 3.358

3.  Interfacing microbial styrene production with a biocompatible cyclopropanation reaction.

Authors:  Stephen Wallace; Emily P Balskus
Journal:  Angew Chem Int Ed Engl       Date:  2015-04-29       Impact factor: 15.336

4.  Artificial Diels-Alderase based on the transmembrane protein FhuA.

Authors:  Hassan Osseili; Daniel F Sauer; Klaus Beckerle; Marcus Arlt; Tomoki Himiyama; Tino Polen; Akira Onoda; Ulrich Schwaneberg; Takashi Hayashi; Jun Okuda
Journal:  Beilstein J Org Chem       Date:  2016-06-24       Impact factor: 2.883

5.  2-Methyl-2,4-pentanediol (MPD) boosts as detergent-substitute the performance of ß-barrel hybrid catalyst for phenylacetylene polymerization.

Authors:  Julia Kinzel; Daniel F Sauer; Marco Bocola; Marcus Arlt; Tayebeh Mirzaei Garakani; Andreas Thiel; Klaus Beckerle; Tino Polen; Jun Okuda; Ulrich Schwaneberg
Journal:  Beilstein J Org Chem       Date:  2017-07-31       Impact factor: 2.883

6.  Atroposelective antibodies as a designed protein scaffold for artificial metalloenzymes.

Authors:  Takuma Adachi; Akira Harada; Hiroyasu Yamaguchi
Journal:  Sci Rep       Date:  2019-09-19       Impact factor: 4.379

Review 7.  Unlocking the therapeutic potential of artificial metalloenzymes.

Authors:  Katsunori Tanaka; Kenward Vong
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2020       Impact factor: 3.493

8.  Engineering a Metathesis-Catalyzing Artificial Metalloenzyme Based on HaloTag.

Authors:  Sandro Fischer; Thomas R Ward; Alexandria D Liang
Journal:  ACS Catal       Date:  2021-05-12       Impact factor: 13.084

9.  Controlled Ligand Exchange Between Ruthenium Organometallic Cofactor Precursors and a Naïve Protein Scaffold Generates Artificial Metalloenzymes Catalysing Transfer Hydrogenation.

Authors:  George S Biggs; Oskar James Klein; Sarah L Maslen; J Mark Skehel; Trevor J Rutherford; Stefan M V Freund; Florian Hollfelder; Sally R Boss; Paul D Barker
Journal:  Angew Chem Int Ed Engl       Date:  2021-03-26       Impact factor: 15.336
  9 in total

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