Literature DB >> 22211022

Effects of long term ethanol consumption on cell death in liver.

Subir Kumar Das, Sukhes Mukherjee, D M Vasudevan.   

Abstract

Apoptosis plays an important role in cellular homeostasis. In this study we have investigated whether apoptosis is a contributory factor to alcohol induced liver damage. Long term ethanol (1.6 g/kg body weight/day) exposure augmented liver apoptosis as reflected by high frequency of positive TUNEL staining nuclei and by an increased activity of caspase-3 and -8. Our study provides evidence that long-term ethanol consumption triggers apoptotic process in the liver.

Entities:  

Keywords:  Apoptosis; Caspase; Ethanol; TUNEL

Year:  2010        PMID： 22211022      PMCID： PMC3068761          DOI： 10.1007/s12291-010-0094-y

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN： 0970-1915


  17 in total

1.  Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation.

Authors:  Ayman Koteish; ShiQi Yang; HuiZhi Lin; Xiawen Huang; Anna Mae Diehl
Journal:  J Biol Chem       Date:  2002-01-25       Impact factor: 5.157

Review 2.  Apoptosis and the maintenance of homoeostasis in the immune system.

Authors:  B A Osborne
Journal:  Curr Opin Immunol       Date:  1996-04       Impact factor: 7.486

3.  Protective effect of resveratrol and vitamin E against ethanol-induced oxidative damage in mice: biochemical and immunological basis.

Authors:  Subir Kumar Das; Sukhes Mukherjee; Geetanjali Gupta; D N Rao; D M Vasudevan
Journal:  Indian J Biochem Biophys       Date:  2010-02       Impact factor: 1.918

4.  Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication.

Authors:  I Kurose; H Higuchi; S Miura; H Saito; N Watanabe; R Hokari; M Hirokawa; M Takaishi; S Zeki; T Nakamura; H Ebinuma; S Kato; H Ishii
Journal:  Hepatology       Date:  1997-02       Impact factor: 17.425

Review 5.  Mechanisms of caspase activation and inhibition during apoptosis.

Authors:  Yigong Shi
Journal:  Mol Cell       Date:  2002-03       Impact factor: 17.970

Review 6.  Apoptosis mediated by the Fas system.

Authors:  S Nagata
Journal:  Prog Mol Subcell Biol       Date:  1996

7.  Time-dependent effects of ethanol on blood oxidative stress parameters and cytokines.

Authors:  Subir Kumar Das; Sowmya Varadhan; Geetanjali Gupta; Sukhes Mukherjee; L Dhanya; D N Rao; D M Vasudevan
Journal:  Indian J Biochem Biophys       Date:  2009-02       Impact factor: 1.918

8.  Exogenous thioredoxin prevents ethanol-induced oxidative damage and apoptosis in mouse liver.

Authors:  Jessica I Cohen; Sanjoy Roychowdhury; Patricia M DiBello; Donald W Jacobsen; Laura E Nagy
Journal:  Hepatology       Date:  2009-05       Impact factor: 17.425

9.  Zinc supplementation inhibits hepatic apoptosis in mice subjected to a long-term ethanol exposure.

Authors:  Zhanxiang Zhou; Jie Liu; Zhenyuan Song; Craig J McClain; Y James Kang
Journal:  Exp Biol Med (Maywood)       Date:  2008-03-28

Review 10.  Oxidative stress and alcoholic liver disease.

Authors:  J C Fernández-Checa; N Kaplowitz; A Colell; C García-Ruiz
Journal:  Alcohol Health Res World       Date:  1997
View more
  2 in total

1.  Hepatoprotective effects of chamazulene against alcohol-induced liver damage by alleviation of oxidative stress in rat models.

Authors:  Xu Wang; Ke Dong; Yujing Ma; Qizhi Jin; Shujun Yin; Shan Wang
Journal:  Open Life Sci       Date:  2020-04-20       Impact factor: 0.938

2.  How does ethanol induce apoptotic cell death of SK-N-SH neuroblastoma cells.

Authors:  Yong Moon; Yongil Kwon; Shun Yu
Journal:  Neural Regen Res       Date:  2013-07-15       Impact factor: 5.135
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.