Literature DB >> 11931755

Mechanisms of caspase activation and inhibition during apoptosis.

Yigong Shi1.   

Abstract

Caspases are central components of the machinery responsible for apoptosis. Recent structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome have revealed a conserved mechanism of caspase activation and inhibition. This article reviews these latest advances and presents our current understanding of caspase regulation during apoptosis.

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Year:  2002        PMID： 11931755     DOI： 10.1016/s1097-2765(02)00482-3

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  400 in total

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