Literature DB >> 22203593

Partial excision of blaKPC from Tn4401 in carbapenem-resistant Klebsiella pneumoniae.

Liang Chen1, Kalyan D Chavda, José R Mediavilla, Michael R Jacobs, Michael H Levi, Robert A Bonomo, Barry N Kreiswirth.   

Abstract

We describe a novel Tn4401 variant (Tn4401d) in epidemic Klebsiella pneumoniae clone ST258, from which a partial bla(KPC) fragment has been excised along with ISKpn7 and a partial tnpA fragment. Nested-PCR experiments confirmed that this region can be removed from distinct Tn4401 isoforms in both K. pneumoniae and Escherichia coli. This study highlights that the region surrounding bla(KPC) is undergoing recombination and that Tn4401 itself is heterogeneous and highly plastic.

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Year:  2011        PMID： 22203593      PMCID： PMC3294926          DOI： 10.1128/AAC.06182-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Modified Hodge and EDTA-disk synergy tests to screen metallo-beta-lactamase-producing strains of Pseudomonas and Acinetobacter species.

Authors:  K Lee; Y Chong; H B Shin; Y A Kim; D Yong; J H Yum
Journal:  Clin Microbiol Infect       Date:  2001-02       Impact factor: 8.067

2.  Functional characterization of Tn4401, a Tn3-based transposon involved in blaKPC gene mobilization.

Authors:  Gaelle Cuzon; Thierry Naas; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2011-08-15       Impact factor: 5.191

3.  The spread of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae to upstate New York.

Authors:  Ben M Lomaestro; Ellis H Tobin; Wenchi Shang; Thomas Gootz
Journal:  Clin Infect Dis       Date:  2006-06-19       Impact factor: 9.079

4.  Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates.

Authors:  Laure Diancourt; Virginie Passet; Jan Verhoef; Patrick A D Grimont; Sylvain Brisse
Journal:  J Clin Microbiol       Date:  2005-08       Impact factor: 5.948

5.  Identification of plasmids by PCR-based replicon typing.

Authors:  Alessandra Carattoli; Alessia Bertini; Laura Villa; Vincenzo Falbo; Katie L Hopkins; E John Threlfall
Journal:  J Microbiol Methods       Date:  2005-06-02       Impact factor: 2.363

6.  High-level carbapenem resistance in a Klebsiella pneumoniae clinical isolate is due to the combination of bla(ACT-1) beta-lactamase production, porin OmpK35/36 insertional inactivation, and down-regulation of the phosphate transport porin phoe.

Authors:  Frank M Kaczmarek; Fadia Dib-Hajj; Wenchi Shang; Thomas D Gootz
Journal:  Antimicrob Agents Chemother       Date:  2006-10       Impact factor: 5.191

7.  Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258.

Authors:  Brandon Kitchel; J Kamile Rasheed; Jean B Patel; Arjun Srinivasan; Shiri Navon-Venezia; Yehuda Carmeli; Alma Brolund; Christian G Giske
Journal:  Antimicrob Agents Chemother       Date:  2009-06-08       Impact factor: 5.191

8.  Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4.

Authors:  Daniel J Wolter; Philip M Kurpiel; Neil Woodford; Marie-France I Palepou; Richard V Goering; Nancy D Hanson
Journal:  Antimicrob Agents Chemother       Date:  2008-11-17       Impact factor: 5.191

9.  Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene.

Authors:  Thierry Naas; Gaelle Cuzon; Maria-Virginia Villegas; Marie-Frédérique Lartigue; John P Quinn; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2008-01-28       Impact factor: 5.191

10.  Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital.

Authors:  Thomas D Gootz; Mary Kay Lescoe; Fadia Dib-Hajj; Brian A Dougherty; Wen He; Phyllis Della-Latta; Richard C Huard
Journal:  Antimicrob Agents Chemother       Date:  2009-03-02       Impact factor: 5.191
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  19 in total

1.  KPC-4 Is encoded within a truncated Tn4401 in an IncL/M plasmid, pNE1280, isolated from Enterobacter cloacae and Serratia marcescens.

Authors:  Kendall A Bryant; Trevor C Van Schooneveld; Ishwor Thapa; Dhundy Bastola; Laurina O Williams; Thomas J Safranek; Steven H Hinrichs; Mark E Rupp; Paul D Fey
Journal:  Antimicrob Agents Chemother       Date:  2012-10-15       Impact factor: 5.191

2.  Complete nucleotide sequence of the first KPC-2- and SHV-12-encoding IncX plasmid, pKpS90, from Klebsiella pneumoniae.

Authors:  Najiby Kassis-Chikhani; Lionel Frangeul; Laurence Drieux; Christian Sengelin; Vincent Jarlier; Sylvain Brisse; Guillaume Arlet; Dominique Decré
Journal:  Antimicrob Agents Chemother       Date:  2012-10-22       Impact factor: 5.191

3.  A swordless knight: epidemiology and molecular characteristics of the blaKPC-negative sequence type 258 Klebsiella pneumoniae clone.

Authors:  Amos Adler; Svetlana Paikin; Yelena Sterlin; Josef Glick; Rotem Edgar; Rima Aronov; Mitchell J Schwaber; Yehuda Carmeli
Journal:  J Clin Microbiol       Date:  2012-07-18       Impact factor: 5.948

4.  Molecular survey of the dissemination of two blaKPC-harboring IncFIA plasmids in New Jersey and New York hospitals.

Authors:  Liang Chen; Kalyan D Chavda; Roberto G Melano; Tao Hong; Albert D Rojtman; Michael R Jacobs; Robert A Bonomo; Barry N Kreiswirth
Journal:  Antimicrob Agents Chemother       Date:  2014-02-03       Impact factor: 5.191

5.  Genetic Factors Associated with Enhanced bla KPC Expression in Tn3/Tn4401 Chimeras.

Authors:  Jiansheng Huang; Xiaolei Hu; Yunan Zhao; Yang Shi; Hui Ding; Jianfen Xv; Jianmin Ren; Rongzhen Wu; Zhigang Zhao
Journal:  Antimicrob Agents Chemother       Date:  2020-02-21       Impact factor: 5.191

6.  Enhanced Klebsiella pneumoniae Carbapenemase Expression from a Novel Tn4401 Deletion.

Authors:  Anita Cheruvanky; Nicole Stoesser; Anna E Sheppard; Derrick W Crook; Paul S Hoffman; Erin Weddle; Joanne Carroll; Costi D Sifri; Weidong Chai; Katie Barry; Girija Ramakrishnan; Amy J Mathers
Journal:  Antimicrob Agents Chemother       Date:  2017-05-24       Impact factor: 5.191

7.  Expansion and evolution of a virulent, extensively drug-resistant (polymyxin B-resistant), QnrS1-, CTX-M-2-, and KPC-2-producing Klebsiella pneumoniae ST11 international high-risk clone.

Authors:  Leonardo Neves Andrade; Lúcia Vitali; Gilberto Gambero Gaspar; Fernando Bellissimo-Rodrigues; Roberto Martinez; Ana Lúcia Costa Darini
Journal:  J Clin Microbiol       Date:  2014-05-07       Impact factor: 5.948

8.  Complete nucleotide sequences of blaKPC-4- and blaKPC-5-harboring IncN and IncX plasmids from Klebsiella pneumoniae strains isolated in New Jersey.

Authors:  Liang Chen; Kalyan D Chavda; Henry S Fraimow; José R Mediavilla; Roberto G Melano; Michael R Jacobs; Robert A Bonomo; Barry N Kreiswirth
Journal:  Antimicrob Agents Chemother       Date:  2012-10-31       Impact factor: 5.191

9.  Molecular Evolution of a Klebsiella pneumoniae ST278 Isolate Harboring blaNDM-7 and Involved in Nosocomial Transmission.

Authors:  Tarah Lynch; Liang Chen; Gisele Peirano; Dan B Gregson; Deirdre L Church; John Conly; Barry N Kreiswirth; Johann D Pitout
Journal:  J Infect Dis       Date:  2016-06-09       Impact factor: 5.226

10.  Complete sequences of KPC-2-encoding plasmid p628-KPC and CTX-M-55-encoding p628-CTXM coexisted in Klebsiella pneumoniae.

Authors:  Li Wang; Haihong Fang; Jiao Feng; Zhe Yin; Xiaofang Xie; Xueming Zhu; Jie Wang; Weijun Chen; Ruisheng Yang; Hong Du; Dongsheng Zhou
Journal:  Front Microbiol       Date:  2015-08-19       Impact factor: 5.640
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