Literature DB >> 22203375

Lamellar macular hole following intravitreal pegaptanib sodium (Macugen) injection for diabetic macular edema.

Giuseppe Querques1, Anna V Bux, Cristiana Iaculli, Nicola Delle Noci.   

Abstract

To report on a patient who developed a lamellar macular hole 1 month after an intravitreal pegaptanib sodium injection. Interventional case report. A 66 year old patient developed a lamellar macular hole 1 month after an intravitreal pegaptanib sodium injection for diabetic macular edema (DME). The pathogenesis of the lamellar macular hole in our case can be attributed to the intravitreal injection that may have induced vitreous incarceration, causing vitreoretinal traction at the macula and development of a lamellar macular hole. Alternatively or in association, pegaptanib itself may have caused the lamellar macular hole by inducing sudden reduction of the DME and exacerbation of tangential traction of the posterior vitreous on the overlying macular retina. Lamellar macular hole seems to be a potential complication of pegaptanib injection even in patients without pretreatment clinically detectable vitreomacular traction.

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Year:  2011        PMID： 22203375     DOI： 10.1007/s10792-011-9493-1

Source DB:  PubMed          Journal:  Int Ophthalmol        ISSN： 0165-5701            Impact factor:   2.031


  7 in total

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Authors:  Evangelos S Gragoudas; Anthony P Adamis; Emmett T Cunningham; Matthew Feinsod; David R Guyer
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7.  Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study.

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  7 in total
  2 in total

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Authors:  Athanasios Karamitsos; Konstantina N Sorkou; Joy Bhagey; Roxane J Hillier; Vasileios T Papastavrou
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2.  Vitreoretinal interface abnormalities in patients treatedwith ranibizumab for diabetic macular oedema.

Authors:  Yun Wong; David H W Steel; Maged S Habib; Alex Stubbing-Moore; Dalvir Bajwa; Peter J Avery
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  2 in total

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