Literature DB >> 22200773

Dnmt3a silences hematopoietic stem cell self-renewal.

Jennifer J Trowbridge1, Stuart H Orkin.   

Abstract

DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.

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Year:  2011        PMID： 22200773     DOI： 10.1038/ng.1043

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  12 in total

1.  Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.

Authors:  Qing Gao; Eveline J Steine; M Inmaculada Barrasa; Dirk Hockemeyer; Mathias Pawlak; Dongdong Fu; Seshamma Reddy; George W Bell; Rudolf Jaenisch
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-19       Impact factor: 11.205

2.  Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation.

Authors:  Eric Hervouet; François M Vallette; Pierre-François Cartron
Journal:  Epigenetics       Date:  2009-10-21       Impact factor: 4.528

3.  DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

Authors:  Ann-Marie Bröske; Lena Vockentanz; Shabnam Kharazi; Matthew R Huska; Elena Mancini; Marina Scheller; Christiane Kuhl; Andreas Enns; Marco Prinz; Rudolf Jaenisch; Claus Nerlov; Achim Leutz; Miguel A Andrade-Navarro; Sten Eirik W Jacobsen; Frank Rosenbauer
Journal:  Nat Genet       Date:  2009-10-04       Impact factor: 38.330

Review 4.  Exposing the DNA methylome iceberg.

Authors:  Matladi N Ndlovu; Hélène Denis; François Fuks
Journal:  Trends Biochem Sci       Date:  2011-04-14       Impact factor: 13.807

5.  Dnmt3a is essential for hematopoietic stem cell differentiation.

Authors:  Grant A Challen; Deqiang Sun; Mira Jeong; Min Luo; Jaroslav Jelinek; Jonathan S Berg; Christoph Bock; Aparna Vasanthakumar; Hongcang Gu; Yuanxin Xi; Shoudan Liang; Yue Lu; Gretchen J Darlington; Alexander Meissner; Jean-Pierre J Issa; Lucy A Godley; Wei Li; Margaret A Goodell
Journal:  Nat Genet       Date:  2011-12-04       Impact factor: 38.330

6.  DNMT3A mutations in acute myeloid leukemia.

Authors:  Timothy J Ley; Li Ding; Matthew J Walter; Michael D McLellan; Tamara Lamprecht; David E Larson; Cyriac Kandoth; Jacqueline E Payton; Jack Baty; John Welch; Christopher C Harris; Cheryl F Lichti; R Reid Townsend; Robert S Fulton; David J Dooling; Daniel C Koboldt; Heather Schmidt; Qunyuan Zhang; John R Osborne; Ling Lin; Michelle O'Laughlin; Joshua F McMichael; Kim D Delehaunty; Sean D McGrath; Lucinda A Fulton; Vincent J Magrini; Tammi L Vickery; Jasreet Hundal; Lisa L Cook; Joshua J Conyers; Gary W Swift; Jerry P Reed; Patricia A Alldredge; Todd Wylie; Jason Walker; Joelle Kalicki; Mark A Watson; Sharon Heath; William D Shannon; Nobish Varghese; Rakesh Nagarajan; Peter Westervelt; Michael H Tomasson; Daniel C Link; Timothy A Graubert; John F DiPersio; Elaine R Mardis; Richard K Wilson
Journal:  N Engl J Med       Date:  2010-11-10       Impact factor: 91.245

7.  Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes.

Authors:  Hao Wu; Volkan Coskun; Jifang Tao; Wei Xie; Weihong Ge; Kazuaki Yoshikawa; En Li; Yi Zhang; Yi Eve Sun
Journal:  Science       Date:  2010-07-23       Impact factor: 47.728

8.  Recurrent DNMT3A mutations in patients with myelodysplastic syndromes.

Authors:  M J Walter; L Ding; D Shen; J Shao; M Grillot; M McLellan; R Fulton; H Schmidt; J Kalicki-Veizer; M O'Laughlin; C Kandoth; J Baty; P Westervelt; J F DiPersio; E R Mardis; R K Wilson; T J Ley; T A Graubert
Journal:  Leukemia       Date:  2011-03-18       Impact factor: 11.528

9.  DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells.

Authors:  Jennifer J Trowbridge; Jonathan W Snow; Jonghwan Kim; Stuart H Orkin
Journal:  Cell Stem Cell       Date:  2009-10-02       Impact factor: 24.633

10.  De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells.

Authors:  Yuko Tadokoro; Hideo Ema; Masaki Okano; En Li; Hiromitsu Nakauchi
Journal:  J Exp Med       Date:  2007-04-09       Impact factor: 14.307
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  18 in total

Review 1.  The Role of Stem Cell DNA Methylation in Colorectal Carcinogenesis.

Authors:  Lele Song; Yuemin Li
Journal:  Stem Cell Rev Rep       Date:  2016-10       Impact factor: 5.739

2.  Longitudinal Analysis of DNA Methylation in CD34+ Hematopoietic Progenitors in Myelodysplastic Syndrome.

Authors:  Yan-Fung Wong; Chris N Micklem; Masataka Taguchi; Hidehiro Itonaga; Yasushi Sawayama; Daisuke Imanishi; Shinichi Nishikawa; Yasushi Miyazaki; Lars Martin Jakt
Journal:  Stem Cells Transl Med       Date:  2014-08-13       Impact factor: 6.940

3.  The R882H substitution in the human de novo DNA methyltransferase DNMT3A disrupts allosteric regulation by the tumor supressor p53.

Authors:  Jonathan E Sandoval; Norbert O Reich
Journal:  J Biol Chem       Date:  2019-10-22       Impact factor: 5.157

4.  Analysis of the genome-wide DNA methylation profile of side population cells in hepatocellular carcinoma.

Authors:  Jing-Ming Zhai; Xiao-Yu Yin; Xun Hou; Xiao-Yi Hao; Jian-Peng Cai; Li-Jian Liang; Long-Juan Zhang
Journal:  Dig Dis Sci       Date:  2013-04-27       Impact factor: 3.199

5.  Targeting the unique methylation pattern of androgen receptor (AR) promoter in prostate stem/progenitor cells with 5-aza-2'-deoxycytidine (5-AZA) leads to suppressed prostate tumorigenesis.

Authors:  Jing Tian; Soo Ok Lee; Liang Liang; Jie Luo; Chiung-Kuei Huang; Lei Li; Yuanjie Niu; Chawnshang Chang
Journal:  J Biol Chem       Date:  2012-09-25       Impact factor: 5.157

Review 6.  Cancer genetics and epigenetics: two sides of the same coin?

Authors:  Jueng Soo You; Peter A Jones
Journal:  Cancer Cell       Date:  2012-07-10       Impact factor: 31.743

7.  Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations.

Authors:  Britta Will; Li Zhou; Thomas O Vogler; Susanna Ben-Neriah; Carolina Schinke; Roni Tamari; Yiting Yu; Tushar D Bhagat; Sanchari Bhattacharyya; Laura Barreyro; Christoph Heuck; Yonkai Mo; Samir Parekh; Christine McMahon; Andrea Pellagatti; Jacqueline Boultwood; Cristina Montagna; Lewis Silverman; Jaroslaw Maciejewski; John M Greally; B Hilda Ye; Alan F List; Christian Steidl; Ulrich Steidl; Amit Verma
Journal:  Blood       Date:  2012-07-02       Impact factor: 22.113

Review 8.  Epigenetic regulation of stem cells differentiating along the neural lineage.

Authors:  Volkan Coskun; Rosemarie Tsoa; Yi E Sun
Journal:  Curr Opin Neurobiol       Date:  2012-07-24       Impact factor: 6.627

9.  DNA methyltransferase3A as a molecular switch mediating the neural tube-to-neural crest fate transition.

Authors:  Na Hu; Pablo Strobl-Mazzulla; Tatjana Sauka-Spengler; Marianne E Bronner
Journal:  Genes Dev       Date:  2012-11-01       Impact factor: 11.361

10.  DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells.

Authors:  Jie Xu; Yue-Ying Wang; Yu-Jun Dai; Wu Zhang; Wei-Na Zhang; Shu-Min Xiong; Zhao-Hui Gu; Kan-Kan Wang; Rong Zeng; Zhu Chen; Sai-Juan Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-04       Impact factor: 11.205
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