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Literature DB >> 22200572

A novel family of toxin/antitoxin proteins in Bacillus species.

Laura E Holberger¹, Fernando Garza-Sánchez, James Lamoureux, David A Low, Christopher S Hayes.

Abstract

The C-terminal regions (CT) of Pfam PF04740 proteins share significant sequence identity with the toxic CdiA-CT effector domains of contact-dependent growth inhibition (CDI) systems. In accord with this homology, we find that several PF04740 CT domains inhibit cell growth when expressed in Escherichia coli. This growth inhibition is specifically blocked by antitoxin proteins encoded downstream of each PF04740 gene. The YobL-CT, YxiD-CT and YqcG-CT domains from Bacillus subtilis 168 have cytotoxic RNase activities, which are neutralized by the binding of cognate YobK, YxxD and YqcF antitoxin proteins, respectively. Our results show that PF04740 proteins represent a new family of toxin/antitoxin pairs that are widely distributed in Gram-positive bacteria.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2011 PMID： 22200572 PMCID： PMC3259279 DOI： 10.1016/j.febslet.2011.12.020

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

23 in total

1. DNA binding and degradation by the HNH protein ColE7.

Authors: Kuo-Chiang Hsia; Kin-Fu Chak; Po-Huang Liang; Yi-Sheng Cheng; Wen-Yen Ku; Hanna S Yuan
Journal: Structure Date: 2004-02 Impact factor: 5.006

Review 2. Prokaryotic toxin-antitoxin stress response loci.

Authors: Kenn Gerdes; Susanne K Christensen; Anders Løbner-Olesen
Journal: Nat Rev Microbiol Date: 2005-05 Impact factor: 60.633

3. Contact-dependent inhibition of growth in Escherichia coli.

Authors: Stephanie K Aoki; Rupinderjit Pamma; Aaron D Hernday; Jessica E Bickham; Bruce A Braaten; David A Low
Journal: Science Date: 2005-08-19 Impact factor: 47.728

4. Engineering controllable protein degradation.

Authors: Kathleen E McGinness; Tania A Baker; Robert T Sauer
Journal: Mol Cell Date: 2006-06-09 Impact factor: 17.970

5. Bacillus subtilis functional genomics: genome-wide analysis of the DegS-DegU regulon by transcriptomics and proteomics.

Authors: U Mäder; H Antelmann; T Buder; M K Dahl; M Hecker; G Homuth
Journal: Mol Genet Genomics Date: 2002-11-16 Impact factor: 3.291

Review 6. The DegS/DegU and ComP/ComA two-component systems are part of a network controlling degradative enzyme synthesis and competence in Bacillus subtilis.

Authors: F Kunst; T Msadek; J Bignon; G Rapoport
Journal: Res Microbiol Date: 1994 Jun-Aug Impact factor: 3.992

7. Homing in on the role of transition metals in the HNH motif of colicin endonucleases.

Authors: A J Pommer; U C Kühlmann; A Cooper; A M Hemmings; G R Moore; R James; C Kleanthous
Journal: J Biol Chem Date: 1999-09-17 Impact factor: 5.157

8. The ESAT-6/WXG100 superfamily -- and a new Gram-positive secretion system?

Authors: Mark J Pallen
Journal: Trends Microbiol Date: 2002-05 Impact factor: 17.079

9. Comparative genomics of the FtsK-HerA superfamily of pumping ATPases: implications for the origins of chromosome segregation, cell division and viral capsid packaging.

Authors: Lakshminarayan M Iyer; Kira S Makarova; Eugene V Koonin; L Aravind
Journal: Nucleic Acids Res Date: 2004-10-05 Impact factor: 16.971

10. Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection.

Authors: Tomoya Baba; Takeshi Ara; Miki Hasegawa; Yuki Takai; Yoshiko Okumura; Miki Baba; Kirill A Datsenko; Masaru Tomita; Barry L Wanner; Hirotada Mori
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34 in total

1. Differential Modulation of Listeria monocytogenes Fitness, In Vitro Virulence, and Transcription of Virulence-Associated Genes in Response to the Presence of Different Microorganisms.

Authors: Evangelia A Zilelidou; Varvara Milina; Spiros Paramithiotis; Georgia Zoumpopoulou; Sofia V Poimenidou; Eleni Mavrogonatou; Dimitris Kletsas; Konstantinos Papadimitriou; Effie Tsakalidou; Panagiotis N Skandamis
Journal: Appl Environ Microbiol Date: 2020-08-18 Impact factor: 4.792

2. Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics.

Authors: Dapeng Zhang; Robson F de Souza; Vivek Anantharaman; Lakshminarayan M Iyer; L Aravind
Journal: Biol Direct Date: 2012-06-25 Impact factor: 4.540

A novel family of toxin/antitoxin proteins in Bacillus species.

1. DNA binding and degradation by the HNH protein ColE7.

Review 2. Prokaryotic toxin-antitoxin stress response loci.

3. Contact-dependent inhibition of growth in Escherichia coli.

4. Engineering controllable protein degradation.

5. Bacillus subtilis functional genomics: genome-wide analysis of the DegS-DegU regulon by transcriptomics and proteomics.

Review 6. The DegS/DegU and ComP/ComA two-component systems are part of a network controlling degradative enzyme synthesis and competence in Bacillus subtilis.

7. Homing in on the role of transition metals in the HNH motif of colicin endonucleases.

8. The ESAT-6/WXG100 superfamily -- and a new Gram-positive secretion system?

9. Comparative genomics of the FtsK-HerA superfamily of pumping ATPases: implications for the origins of chromosome segregation, cell division and viral capsid packaging.

10. Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection.

1. Differential Modulation of Listeria monocytogenes Fitness, In Vitro Virulence, and Transcription of Virulence-Associated Genes in Response to the Presence of Different Microorganisms.

2. Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics.

3. Contact-dependent growth inhibition toxins exploit multiple independent cell-entry pathways.

4. CdiA from Enterobacter cloacae delivers a toxic ribosomal RNase into target bacteria.

5. Can't you hear me knocking: contact-dependent competition and cooperation in bacteria.

6. A Combinatorial Kin Discrimination System in Bacillus subtilis.

7. Introducing the new bacterial branch of the RNase A superfamily.

8. EssD, a Nuclease Effector of the Staphylococcus aureus ESS Pathway.

Review 9. Contact-Dependent Growth Inhibition (CDI) and CdiB/CdiA Two-Partner Secretion Proteins.

Review 10. Bacterial contact-dependent growth inhibition.