OBJECTIVE: Coronary artery calcification has been associated with higher mortality in coronary artery disease and chronic kidney disease. This study aimed to correlate coronary artery calcification score (CACS) with all-cause and cardiovascular mortalities in hemodialysis (HD) patients. DESIGN, SETTING, SUBJECTS: A survival analysis was conducted in 200 HD patients. CACS was assessed by multidetector-row computed tomography and stratified as tertiles: group 1 (0∼105 U), group 2 (110∼1067 U), and group 3 (1094∼15481 U). The duration of follow-up was 7 years and 4 months. Kaplan-Meier method and Cox proportional hazard analysis adjusted for age and HD duration were performed to examine the impact of CACS on survival. MAIN OUTCOME MEASURE: All-cause and cardiovascular mortalities were measured. RESULTS: The cumulative all-cause and cardiovascular mortalities of group 1 were significantly lower than those of groups 2 and 3 (all-cause mortality: 7.6% vs. 43.3% and 52.2%, respectively, cardiovascular mortality: 3.0% vs. 22.4% and 26.9%, respectively). Cox proportional hazard analysis adjusted for age and HD duration revealed that all-cause and cardiovascular mortalities of group 1 were significantly lower than those of groups 2 and 3. CONCLUSION: CACS is helpful to predict prognosis of HD patients independently of age and HD duration.
OBJECTIVE:Coronary artery calcification has been associated with higher mortality in coronary artery disease and chronic kidney disease. This study aimed to correlate coronary artery calcification score (CACS) with all-cause and cardiovascular mortalities in hemodialysis (HD) patients. DESIGN, SETTING, SUBJECTS: A survival analysis was conducted in 200 HDpatients. CACS was assessed by multidetector-row computed tomography and stratified as tertiles: group 1 (0∼105 U), group 2 (110∼1067 U), and group 3 (1094∼15481 U). The duration of follow-up was 7 years and 4 months. Kaplan-Meier method and Cox proportional hazard analysis adjusted for age and HD duration were performed to examine the impact of CACS on survival. MAIN OUTCOME MEASURE: All-cause and cardiovascular mortalities were measured. RESULTS: The cumulative all-cause and cardiovascular mortalities of group 1 were significantly lower than those of groups 2 and 3 (all-cause mortality: 7.6% vs. 43.3% and 52.2%, respectively, cardiovascular mortality: 3.0% vs. 22.4% and 26.9%, respectively). Cox proportional hazard analysis adjusted for age and HD duration revealed that all-cause and cardiovascular mortalities of group 1 were significantly lower than those of groups 2 and 3. CONCLUSION: CACS is helpful to predict prognosis of HDpatients independently of age and HD duration.
Authors: Da Shang; Qionghong Xie; Bin Shang; Min Zhang; Li You; Chuan-Ming Hao; Tongying Zhu Journal: Biomed Res Int Date: 2017-02-22 Impact factor: 3.411
Authors: Marta Cano-Megías; Pablo Guisado-Vasco; Hanane Bouarich; Gabriel de Arriba-de la Fuente; Patricia de Sequera-Ortiz; Concepción Álvarez-Sanz; Diego Rodríguez-Puyol Journal: BMC Nephrol Date: 2019-05-28 Impact factor: 2.388