| Literature DB >> 22197620 |
Domenico Ribatti1, Valentin Djonov.
Abstract
Intussusception is an alternative to the sprouting mode of angiogenesis. The advantage of this mechanism of vascular growth is that blood vessels are generated more rapidly and the capillaries thereby formed are less leaky. This review article summarizes our current knowledge concerning the role played by intussusceptive microvascular growth in tumor growth. Interestingly, an angiogenic switch from sprouting to intussusceptive angiogenesis occurs after treatment with angiogenesis inhibitors and may be considered as a tumor-protective adaptative response.Entities:
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Year: 2011 PMID： 22197620 DOI： 10.1016/j.canlet.2011.10.040
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679