PURPOSE: This study aimed to (1) examine changes in dyspnea, global pulmonary function test (PFT) results, and functional activity on ventilation (V)/perfusion (Q) single-photon emission computerized tomography (SPECT) scans during the course of radiation (RT), and (2) factors associated with the changes in patients with non-small-cell lung cancer (NSCLC). METHODS AND MATERIALS: Fifty-six stage I to III NSCLC patients treated with definitive RT with or without chemotherapy were enrolled prospectively. Dyspnea was graded according to Common Terminology Criteria for Adverse Events version 3.0 prior to and weekly during RT. V/Q SPECT-computed tomography (CT) and PFTs were performed prior to and during RT at approximately 45 Gy. Functions of V and Q activities were assessed using a semiquantitative scoring of SPECT images. RESULTS: Breathing improved significantly at the third week (mean dyspnea grade, 0.8 vs. 0.6; paired t-test p = 0.011) and worsened during the later course of RT (p > 0.05). Global PFT results did not change significantly, while regional lung function on V/Q SPECT improved significantly after ∼45 Gy. The V defect score (DS) was 4.9 pre-RT versus 4.3 during RT (p = 0.01); Q DS was 4.3 pre-RT versus 4.0 during RT (p < 0.01). Improvements in V and Q functions were seen primarily in the ipsilateral lung (V DS, 1.9 pre-RT versus 1.4 during RT, p < 0.01; Q DS, 1.7 pre-RT versus 1.5 during RT, p < 0.01). Baseline primary tumor volume was significantly correlated with pre-RT V/Q DS (p < 0.01). Patients with central lung tumors had greater interval changes in V and Q than those with more peripheral tumors (p <0.05 for both V and Q DS). CONCLUSIONS: Regional ventilation and perfusion improved during RT at 45 Gy. This suggests that adaptive planning based on V/Q SPECT during RT may allow sparing of functionally recoverable lung tissue. Published by Elsevier Inc.
PURPOSE: This study aimed to (1) examine changes in dyspnea, global pulmonary function test (PFT) results, and functional activity on ventilation (V)/perfusion (Q) single-photon emission computerized tomography (SPECT) scans during the course of radiation (RT), and (2) factors associated with the changes in patients with non-small-cell lung cancer (NSCLC). METHODS AND MATERIALS: Fifty-six stage I to III NSCLCpatients treated with definitive RT with or without chemotherapy were enrolled prospectively. Dyspnea was graded according to Common Terminology Criteria for Adverse Events version 3.0 prior to and weekly during RT. V/Q SPECT-computed tomography (CT) and PFTs were performed prior to and during RT at approximately 45 Gy. Functions of V and Q activities were assessed using a semiquantitative scoring of SPECT images. RESULTS: Breathing improved significantly at the third week (mean dyspnea grade, 0.8 vs. 0.6; paired t-test p = 0.011) and worsened during the later course of RT (p > 0.05). Global PFT results did not change significantly, while regional lung function on V/Q SPECT improved significantly after ∼45 Gy. The V defect score (DS) was 4.9 pre-RT versus 4.3 during RT (p = 0.01); Q DS was 4.3 pre-RT versus 4.0 during RT (p < 0.01). Improvements in V and Q functions were seen primarily in the ipsilateral lung (V DS, 1.9 pre-RT versus 1.4 during RT, p < 0.01; Q DS, 1.7 pre-RT versus 1.5 during RT, p < 0.01). Baseline primary tumor volume was significantly correlated with pre-RT V/Q DS (p < 0.01). Patients with central lung tumors had greater interval changes in V and Q than those with more peripheral tumors (p <0.05 for both V and Q DS). CONCLUSIONS: Regional ventilation and perfusion improved during RT at 45 Gy. This suggests that adaptive planning based on V/Q SPECT during RT may allow sparing of functionally recoverable lung tissue. Published by Elsevier Inc.
Authors: Y Seppenwoolde; S H Muller; J C Theuws; P Baas; J S Belderbos; L J Boersma; J V Lebesque Journal: Int J Radiat Oncol Biol Phys Date: 2000-06-01 Impact factor: 7.038
Authors: Judith A Christian; Mike Partridge; Elena Nioutsikou; Gary Cook; Helen A McNair; Bernadette Cronin; Frederic Courbon; James L Bedford; Michael Brada Journal: Radiother Oncol Date: 2005-11-07 Impact factor: 6.280
Authors: Gerben R Borst; Katrien De Jaeger; José S A Belderbos; Sjaak A Burgers; Joos V Lebesque Journal: Int J Radiat Oncol Biol Phys Date: 2005-07-01 Impact factor: 7.038
Authors: Sarah M McGuire; Sumin Zhou; Lawrence B Marks; Mark Dewhirst; Fang-Fang Yin; Shiva K Das Journal: Int J Radiat Oncol Biol Phys Date: 2006-12-01 Impact factor: 7.038
Authors: S K Das; M M Miften; S Zhou; M Bell; M T Munley; C S Whiddon; O Craciunescu; A H Baydush; T Wong; J G Rosenman; M W Dewhirst; L B Marks Journal: Med Phys Date: 2004-06 Impact factor: 4.071
Authors: Konstantin Lavrenkov; Judith A Christian; Mike Partridge; Elena Niotsikou; Gary Cook; Michelle Parker; James L Bedford; Michael Brada Journal: Radiother Oncol Date: 2007-05-09 Impact factor: 6.280
Authors: L J Boersma; E M Damen; R W de Boer; S H Muller; C M Roos; R A Valdés Olmos; N van Zandwijk; J V Lebesque Journal: Radiother Oncol Date: 1994-09 Impact factor: 6.280
Authors: Yvette Seppenwoolde; Martijn Engelsman; Katrien De Jaeger; Sara H Muller; Paul Baas; Daniel L McShan; Benedick A Fraass; Marc L Kessler; José S A Belderbos; Liesbeth J Boersma; Joos V Lebesque Journal: Radiother Oncol Date: 2002-05 Impact factor: 6.280
Authors: Faegheh S Mounessi; Jörg Eckardt; Arne Holstein; Santiago Ewig; Stefan Könemann Journal: Strahlenther Onkol Date: 2019-10-02 Impact factor: 3.621
Authors: Katherina P Farr; Stine Kramer; Azza A Khalil; Anni Morsing; Cai Grau Journal: Eur J Nucl Med Mol Imaging Date: 2015-04-11 Impact factor: 9.236
Authors: Jingbo Wang; Jianzhong Cao; Shuanghu Yuan; Wei Ji; Douglas Arenberg; Jianrong Dai; Paul Stanton; Daniel Tatro; Randall K Ten Haken; Luhua Wang; Feng-Ming Spring Kong Journal: Int J Radiat Oncol Biol Phys Date: 2012-07-24 Impact factor: 7.038
Authors: Tokihiro Yamamoto; Sven Kabus; Cristian Lorenz; Erik Mittra; Julian C Hong; Melody Chung; Neville Eclov; Jacqueline To; Maximilian Diehn; Billy W Loo; Paul J Keall Journal: Int J Radiat Oncol Biol Phys Date: 2014-08-04 Impact factor: 7.038
Authors: Tokihiro Yamamoto; Sven Kabus; Matthieu Bal; Karl Bzdusek; Paul J Keall; Cari Wright; Stanley H Benedict; Megan E Daly Journal: Int J Radiat Oncol Biol Phys Date: 2018-05-04 Impact factor: 7.038
Authors: Hannah Mary T Thomas; Jing Zeng; Howard J Lee; Balu Krishna Sasidharan; Paul E Kinahan; Robert S Miyaoka; Hubert J Vesselle; Ramesh Rengan; Stephen R Bowen Journal: Br J Radiol Date: 2019-08-12 Impact factor: 3.039