| Literature DB >> 22197126 |
Amir Wiser1, Einat Shalom-Paz, Shauna Leigh Reinblatt, Weon-Young Son, Mausumi Das, Togas Tulandi, Hananel Holzer.
Abstract
Fertility decreases with advancing age. This study retrospectively reviewed the results of ovarian stimulation and intrauterine insemination (IUI) in women 40 years old with diminished ovarian reserve or unexplained infertility who underwent treatment with ovarian stimulation/IUI with clomiphene citrate or gonadotrophin and compared them with the results of IVF and in-vitro maturation (IVM) treatments. The main outcome measures were pregnancy and live-birth rates. The profiles of the patients in ovarian stimulation, IVM and IVF groups were comparable. There were no clinical pregnancies in the clomiphene citrate and IVM groups. The clinical-pregnancy rates in the gonadotrophin and IVF groups were 2.6% and 16.9% and the live-birth rates were 2.6% and 13.7%, respectively. Compared with ovarian stimulation, IVF is most effective for women aged 40 years or more. Attempting success with ovarian stimulation or IVM will delay conception unnecessarily.Entities:
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Year: 2011 PMID： 22197126 DOI： 10.1016/j.rbmo.2011.11.007
Source DB: PubMed Journal: Reprod Biomed Online ISSN： 1472-6483 Impact factor: 3.828