OBJECTIVE: To assess oxidative stress status in coronary artery disease (CAD) patients according to gender. DESIGN: Case-controlled, observational, retrospective study. SETTING: Clinical and research center. PATIENT(S): A total of 55 postmenopausal women and 108 men (mean age: 66 ± 9 years), including 72 patients with angiographically proven CAD (CAD(+), 19 women) and a group of 91 age-matched controls (CAD(-), 36 women). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Oxidant/antioxidant balance as a global index (oxidative index) obtained using two commercial assays (d-ROMs and OXY Adsorbent Test, respectively) for estimation of levels of reactive oxygen metabolites and total antioxidant status. RESULT(S): There was a statistically significant difference in oxidative stress status between men and women who were CAD(-) (-0.424 ± 1.3 vs. 0.64 ± 1.1 arbitrary units, respectively), but the CAD(+) women had oxidative stress levels almost three times those of the CAD(+) men (2.45 ± 2.5 vs. 0.9 ± 1.6 arbitrary units, respectively). After adjustment in the multivariate model, age and oxidative stress status in women and diabetes and age in men remained as statistically significant predictors of positive CAD findings. CONCLUSION(S): Oxidative stress status was a powerful predictor of CAD in women. This result may have important implications for the differences between sexes in CAD physiopathology.
OBJECTIVE: To assess oxidative stress status in coronary artery disease (CAD) patients according to gender. DESIGN: Case-controlled, observational, retrospective study. SETTING: Clinical and research center. PATIENT(S): A total of 55 postmenopausal women and 108 men (mean age: 66 ± 9 years), including 72 patients with angiographically proven CAD (CAD(+), 19 women) and a group of 91 age-matched controls (CAD(-), 36 women). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Oxidant/antioxidant balance as a global index (oxidative index) obtained using two commercial assays (d-ROMs and OXY Adsorbent Test, respectively) for estimation of levels of reactive oxygen metabolites and total antioxidant status. RESULT(S): There was a statistically significant difference in oxidative stress status between men and women who were CAD(-) (-0.424 ± 1.3 vs. 0.64 ± 1.1 arbitrary units, respectively), but the CAD(+) women had oxidative stress levels almost three times those of the CAD(+) men (2.45 ± 2.5 vs. 0.9 ± 1.6 arbitrary units, respectively). After adjustment in the multivariate model, age and oxidative stress status in women and diabetes and age in men remained as statistically significant predictors of positive CAD findings. CONCLUSION(S): Oxidative stress status was a powerful predictor of CAD in women. This result may have important implications for the differences between sexes in CAD physiopathology.
Authors: Caroline E McCoach; Ehrin J Armstrong; Satinder Singh; Usman Javed; David Anderson; Khung Keong Yeo; Gregory G Westin; Nasim Hedayati; Ezra A Amsterdam; John R Laird Journal: Vasc Med Date: 2013-02 Impact factor: 3.239
Authors: Melis Sahinoz; Fernando Elijovich; Lale A Ertuglu; Jeanne Ishimwe; Ashley Pitzer; Mohammad Saleem; Naome Mwesigwa; Thomas R Kleyman; Cheryl L Laffer; Annet Kirabo Journal: Antioxid Redox Signal Date: 2021-12-20 Impact factor: 8.401
Authors: Rommel C Morales; Edward S M Bahnson; George E Havelka; Nadiezhda Cantu-Medellin; Eric E Kelley; Melina R Kibbe Journal: Redox Biol Date: 2015-01-13 Impact factor: 11.799