Karolina Szewczyk-Golec1, Paweł Grzelakowski2, Tomasz Ługowski2, Józef Kędziora3. 1. a Chair of Medical Biology, Ludwik Rydygier Collegium Medicum in Bydgoszcz , Nicolaus Copernicus University in Toruń , Bydgoszcz , Poland. 2. b Clinic of Cardiology and Cardiac Surgery , 10. Military Training Hospital , Bydgoszcz , Poland. 3. c Department of Biochemistry, Ludwik Rydygier Collegium Medicum in Bydgoszcz , Nicolaus Copernicus University in Toruń , Bydgoszcz , Poland.
Abstract
OBJECTIVES: Oxidative stress plays a key role in the pathogenesis of coronary artery disease. The aim of this study was to compare the effects of percutaneous transluminal coronary angioplasty (PTCA) and elective coronary angiography (EC) on erythrocytic antioxidant defense in elderly male patients. METHODS: Twenty-three stable angina pectoris (SAP) patients undergoing PTCA and 18 patients with ischemic symptoms scheduled to undergo diagnostic EC were included in the study. The concentrations of malondialdehyde (MDA) and reduced glutathione (GSH) and the activities of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and cytosolic glutathione peroxidase (GSH-Px) were examined in the erythrocytes before, immediately after and 2 weeks following PTCA or EC. RESULTS: The MDA concentrations were significantly higher and SOD-1, CAT, and GSH-Px activities were significantly lower in the PTCA group than in the EC group at baseline. Two weeks after treatment, the activities of the enzymes significantly increased in both groups, whereas the MDA concentrations decreased only in the PTCA patients. CONCLUSIONS: The results confirm that an advanced state of atherosclerosis is related to greater levels of oxidative stress. The study indicates that both procedures may induce antioxidant defenses; however, PTCA exclusively induces a long-term reduction in lipid peroxidation.
OBJECTIVES: Oxidative stress plays a key role in the pathogenesis of coronary artery disease. The aim of this study was to compare the effects of percutaneous transluminal coronary angioplasty (PTCA) and elective coronary angiography (EC) on erythrocytic antioxidant defense in elderly male patients. METHODS: Twenty-three stable angina pectoris (SAP) patients undergoing PTCA and 18 patients with ischemic symptoms scheduled to undergo diagnostic EC were included in the study. The concentrations of malondialdehyde (MDA) and reduced glutathione (GSH) and the activities of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and cytosolic glutathione peroxidase (GSH-Px) were examined in the erythrocytes before, immediately after and 2 weeks following PTCA or EC. RESULTS: The MDA concentrations were significantly higher and SOD-1, CAT, and GSH-Px activities were significantly lower in the PTCA group than in the EC group at baseline. Two weeks after treatment, the activities of the enzymes significantly increased in both groups, whereas the MDA concentrations decreased only in the PTCA patients. CONCLUSIONS: The results confirm that an advanced state of atherosclerosis is related to greater levels of oxidative stress. The study indicates that both procedures may induce antioxidant defenses; however, PTCA exclusively induces a long-term reduction in lipid peroxidation.
Authors: K Kaminski; T Bonda; I Wojtkowska; S Dobrzycki; P Kralisz; K Nowak; P Prokopczuk; E Skrzydlewska; M Kozuch; W J Musial Journal: Acute Card Care Date: 2008
Authors: Piotr Bandosz; Martin O'Flaherty; Wojciech Drygas; Marcin Rutkowski; Jacek Koziarek; Bogdan Wyrzykowski; Kathleen Bennett; Tomasz Zdrojewski; Simon Capewell Journal: BMJ Date: 2012-01-25