Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Necroptosis turns TNF lethal.

Literature DB >> 22195740

Necroptosis turns TNF lethal.

Abstract

In this issue of Immunity, Duprez et al. (2011) demonstrate that necroptosis, a form of regulated necrosis that is mediated by the kinases RIPK1 and RIPK3, underlies the lethal effects of tumor necrosis factor in vivo.

Entities: Disease Gene

Year: 2011 PMID： 22195740 DOI： 10.1016/j.immuni.2011.12.004

Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745

Keyword Cloud
Cited

7 in total

1. The chemical inhibitors of cellular death, PJ34 and Necrostatin-1, down-regulate IL-33 expression in liver.

Authors: Muhammad Imran Arshad; Claire Piquet-Pellorce; Aveline Filliol; Annie L'Helgoualc'h; Catherine Lucas-Clerc; Sandrine Jouan-Lanhouet; Marie-Thérèse Dimanche-Boitrel; Michel Samson
Journal: J Mol Med (Berl) Date: 2015-03-08 Impact factor: 4.599

2. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis.

Authors: Philip A Harris; Deepak Bandyopadhyay; Scott B Berger; Nino Campobasso; Carol A Capriotti; Julie A Cox; Lauren Dare; Joshua N Finger; Sandra J Hoffman; Kirsten M Kahler; Ruth Lehr; John D Lich; Rakesh Nagilla; Robert T Nolte; Michael T Ouellette; Christina S Pao; Michelle C Schaeffer; Angela Smallwood; Helen H Sun; Barbara A Swift; Rachel D Totoritis; Paris Ward; Robert W Marquis; John Bertin; Peter J Gough
Journal: ACS Med Chem Lett Date: 2013-11-04 Impact factor: 4.345

3. Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features.

Authors: Fabio J Pacheco; Frankis G Almaguel; Whitney Evans; Leslimar Rios-Colon; Valery Filippov; Lai S Leoh; Elizabeth Rook-Arena; Melanie Mediavilla-Varela; Marino De Leon; Carlos A Casiano
Journal: Inflamm Res Date: 2014-08-06 Impact factor: 4.575

Necroptosis turns TNF lethal.

1. The chemical inhibitors of cellular death, PJ34 and Necrostatin-1, down-regulate IL-33 expression in liver.

2. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis.

3. Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features.

4. Intratesticular injection of hypertonic saline : non-invasive alternative method for animal castration model.

5. TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor.

Review 6. Output Regulation and Function Optimization of Mitochondria in Eukaryotes.

7. EVER2 protein binds TRADD to promote TNF-α-induced apoptosis.