Raghu Pullakhandam1, Santu Ghosh2, Bharati Kulkarni1, G Bhanuprakash Reddy1, Hemalatha Rajkumar1, Umesh Kapil3, Sila Deb4, Anura V Kurpad5, Harshpal S Sachdev6. 1. National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India. 2. St John's Medical College, Bangalore, India. 3. Institute of Liver and Biliary Sciences, New Delhi, India. 4. Ministry of Health and Family Welfare, New Delhi, India. 5. St John's Medical College, Bangalore, India. a.kurpad@sjri.res.in. 6. Sitaram Bhartia Institute of Science and Research, New Delhi, India. hpssachdev@gmail.com.
Abstract
BACKGROUND/ OBJECTIVES: Population zinc (Zn) status assessment is based on serum zinc concentration (SZC) cut-offs defined by the International Zinc Nutrition Consultative Group (IZiNCG). The objective of this study is to derive reference SZC cut-offs in apparently healthy 1-19 year Indian children and adolescents using comprehensive national nutrition survey (CNNS) data, and to measure the prevalence of Zn deficiency. SUBJECTS/ METHODS: Apparently healthy children (n = 12,473) were selected from the CNNS, by including the highest 2 wealth quintiles, and excluding stunted, thin and obese children, and those with CRP > 5 mg/L, anaemia, hypo-albuminemia, diabetes, recent diarrhoea and history of smoking. The 2.5th centile of age-based distributions defined the SZC cut-offs, used to measure the prevalence of Zn deficiency in India, as against the IZiNCG cut-offs. RESULTS: The present study SZC cut-offs were significantly lower, by 10-18 µg/dL, than the IZiNCG cut-offs; more in adolescents. Prevalence of Zn deficiency in the entire CNNS, with these cut-offs, was 2.7 (<10 years) to 5.5 (10-19 years) times lower than with the IZiNCG cut-offs. No geographical state, nor any age group, had Zn deficiency as a serious public health problem (≥20%). In contrast, with IZiNCG cut-offs, 9-27 states (depending on age group) had a public health problem. CONCLUSIONS: The present study reference SZC cut-offs for Zn deficiency are lower than the IZiNCG cut-offs, and their rigorous selection from a national sample makes them more appropriate for use in India. A re-examination of the global applicability of IZiNCG recommended cut-offs in other LMICs appears appropriate.
BACKGROUND/ OBJECTIVES: Population zinc (Zn) status assessment is based on serum zinc concentration (SZC) cut-offs defined by the International Zinc Nutrition Consultative Group (IZiNCG). The objective of this study is to derive reference SZC cut-offs in apparently healthy 1-19 year Indian children and adolescents using comprehensive national nutrition survey (CNNS) data, and to measure the prevalence of Zn deficiency. SUBJECTS/ METHODS: Apparently healthy children (n = 12,473) were selected from the CNNS, by including the highest 2 wealth quintiles, and excluding stunted, thin and obese children, and those with CRP > 5 mg/L, anaemia, hypo-albuminemia, diabetes, recent diarrhoea and history of smoking. The 2.5th centile of age-based distributions defined the SZC cut-offs, used to measure the prevalence of Zn deficiency in India, as against the IZiNCG cut-offs. RESULTS: The present study SZC cut-offs were significantly lower, by 10-18 µg/dL, than the IZiNCG cut-offs; more in adolescents. Prevalence of Zn deficiency in the entire CNNS, with these cut-offs, was 2.7 (<10 years) to 5.5 (10-19 years) times lower than with the IZiNCG cut-offs. No geographical state, nor any age group, had Zn deficiency as a serious public health problem (≥20%). In contrast, with IZiNCG cut-offs, 9-27 states (depending on age group) had a public health problem. CONCLUSIONS: The present study reference SZC cut-offs for Zn deficiency are lower than the IZiNCG cut-offs, and their rigorous selection from a national sample makes them more appropriate for use in India. A re-examination of the global applicability of IZiNCG recommended cut-offs in other LMICs appears appropriate.
Authors: Janet C King; Kenneth H Brown; Rosalind S Gibson; Nancy F Krebs; Nicola M Lowe; Jonathan H Siekmann; Daniel J Raiten Journal: J Nutr Date: 2015-04-01 Impact factor: 4.798
Authors: Mohammad Yawar Yakoob; Evropi Theodoratou; Afshan Jabeen; Aamer Imdad; Thomas P Eisele; Joy Ferguson; Arnoupe Jhass; Igor Rudan; Harry Campbell; Robert E Black; Zulfiqar A Bhutta Journal: BMC Public Health Date: 2011-04-13 Impact factor: 3.295