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Literature DB >> 22189468

Detecting pleiotropy and epistasis using variance components linkage analysis in jPAP.

Abstract

jPAP (Java Pedigree Analysis Package) performs variance components linkage analysis of either quantitative or discrete traits. Multivariate linkage analysis of two or more traits (all quantitative, all discrete, or any combination) allows the inference of pleiotropy between the traits. The inclusion of multiple quantitative trait loci in linkage analysis allows the inference of epistasis between loci. A user-friendly graphical user interface facilitates the usage of jPAP.

Entities: Chemical

Mesh：

Year: 2011 PMID： 22189468 PMCID： PMC3267992 DOI： 10.1159/000331690

Source DB: PubMed Journal: Hum Hered ISSN： 0001-5652 Impact factor: 0.444

13 in total

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Authors: Gonçalo R Abecasis; Stacey S Cherny; William O Cookson; Lon R Cardon
Journal: Nat Genet Date: 2001-12-03 Impact factor: 38.330

2. Two-dimensional, sex-specific autosomal linkage scan of the number of sodium pump sites.

Authors: Sandra J Hasstedt; Yuanpei Xin; Paul N Hopkins; Steven C Hunt
Journal: J Hypertens Date: 2010-04 Impact factor: 4.844

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Authors: E Sobel; K Lange
Journal: Am J Hum Genet Date: 1996-06 Impact factor: 11.025

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Authors: L Almasy; J Blangero
Journal: Am J Hum Genet Date: 1998-05 Impact factor: 11.025

5. Univariate and bivariate linkage analysis identifies pleiotropic loci underlying lipid levels and type 2 diabetes risk.

Authors: Sandra J Hasstedt; Craig L Hanis; Steven C Elbein
Journal: Ann Hum Genet Date: 2010-07 Impact factor: 1.670

6. Age of onset, age at examination, and other covariates in the analysis of family data.

Authors: R C Elston; V T George
Journal: Genet Epidemiol Date: 1989 Impact factor: 2.135

7. On the irreducibility of a Markov chain defined on a space of genotype configurations by a sampling scheme.

Authors: N Sheehan; A Thomas
Journal: Biometrics Date: 1993-03 Impact factor: 2.571

8. Strategies for multilocus linkage analysis in humans.

Authors: G M Lathrop; J M Lalouel; C Julier; J Ott
Journal: Proc Natl Acad Sci U S A Date: 1984-06 Impact factor: 11.205

9. Regressive logistic and proportional hazards disease models for within-family analyses of measured genotypes, with application to a CYP17 polymorphism and breast cancer.

Authors: Jisheng S Cui; Amanda B Spurdle; Melissa C Southey; Gillian S Dite; Deon J Venter; Margaret R E McCredie; Graham G Giles; Georgia Chenevix-Trench; John L Hopper
Journal: Genet Epidemiol Date: 2003-04 Impact factor: 2.135

Detecting pleiotropy and epistasis using variance components linkage analysis in jPAP.

1. Merlin--rapid analysis of dense genetic maps using sparse gene flow trees.

2. Two-dimensional, sex-specific autosomal linkage scan of the number of sodium pump sites.

3. Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics.

4. Multipoint quantitative-trait linkage analysis in general pedigrees.

5. Univariate and bivariate linkage analysis identifies pleiotropic loci underlying lipid levels and type 2 diabetes risk.

6. Age of onset, age at examination, and other covariates in the analysis of family data.

7. On the irreducibility of a Markov chain defined on a space of genotype configurations by a sampling scheme.

8. Strategies for multilocus linkage analysis in humans.

9. Regressive logistic and proportional hazards disease models for within-family analyses of measured genotypes, with application to a CYP17 polymorphism and breast cancer.

10. Pleiotropy of type 2 diabetes with obesity.

1. APOH interacts with FTO to predispose to healthy thinness.

2. Genetic variants associated with protein C levels.

3. Five linkage regions each harbor multiple type 2 diabetes genes in the African American subset of the GENNID Study.

4. A Copy Number Variant on Chromosome 20q13.3 Implicated in Thinness and Severe Obesity.