Literature DB >> 2218528

Radiation hybrid mapping: a somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes.

D R Cox1, M Burmeister, E R Price, S Kim, R M Myers.   

Abstract

Radiation hybrid (RH) mapping, a somatic cell genetic technique, was developed as a general approach for constructing long-range maps of mammalian chromosomes. This statistical method depends on x-ray breakage of chromosomes to determine the distances between DNA markers, as well as their order on the chromosome. In addition, the method allows the relative likelihoods of alternative marker orders to be determined. The RH procedure was used to map 14 DNA probes from a region of human chromosome 21 spanning 20 megabase pairs. The map was confirmed by pulsed-field gel electrophoretic analysis. The results demonstrate the effectiveness of RH mapping for constructing high-resolution, contiguous maps of mammalian chromosomes.

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Year:  1990        PMID： 2218528     DOI： 10.1126/science.2218528

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  127 in total

1.  Sequence-tagged connectors: a sequence approach to mapping and scanning the human genome.

Authors:  G G Mahairas; J C Wallace; K Smith; S Swartzell; T Holzman; A Keller; R Shaker; J Furlong; J Young; S Zhao; M D Adams; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

2.  Radiation hybrid mapping of the zebrafish genome.

Authors:  N A Hukriede; L Joly; M Tsang; J Miles; P Tellis; J A Epstein; W B Barbazuk; F N Li; B Paw; J H Postlethwait; T J Hudson; L I Zon; J D McPherson; M Chevrette; I B Dawid; S L Johnson; M Ekker
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

3.  A comprehensive view of human chromosome 1.

Authors:  P S White; E P Sulman; C J Porter; T C Matise
Journal:  Genome Res       Date:  1999-10       Impact factor: 9.043

4.  RHdb: the radiation hybrid database.

Authors:  P Rodriguez-Tomé; P Lijnzaad
Journal:  Nucleic Acids Res       Date:  2000-01-01       Impact factor: 16.971

5.  A maize map standard with sequenced core markers, grass genome reference points and 932 expressed sequence tagged sites (ESTs) in a 1736-locus map.

Authors:  G L Davis; M D McMullen; C Baysdorfer; T Musket; D Grant; M Staebell; G Xu; M Polacco; L Koster; S Melia-Hancock; K Houchins; S Chao; E H Coe
Journal:  Genetics       Date:  1999-07       Impact factor: 4.562

6.  RHdb: the Radiation Hybrid database.

Authors:  P Rodriguez-Tomé; P Lijnzaad
Journal:  Nucleic Acids Res       Date:  2001-01-01       Impact factor: 16.971

7.  Point and interval estimates of marker location in radiation hybrid mapping.

Authors:  H M Stringham; M Boehnke; K Lange
Journal:  Am J Hum Genet       Date:  1999-08       Impact factor: 11.025

8.  Interspersed repetitive sequence (IRS)-PCR for typing of whole genome radiation hybrid panels.

Authors:  H Himmelbauer; L C Schalkwyk; H Lehrach
Journal:  Nucleic Acids Res       Date:  2000-01-15       Impact factor: 16.971

9.  RHO--radiation hybrid ordering.

Authors:  A Ben-Dor; B Chor; D Pelleg
Journal:  Genome Res       Date:  2000-03       Impact factor: 9.043

10.  A fast and scalable radiation hybrid map construction and integration strategy.

Authors:  R Agarwala; D L Applegate; D Maglott; G D Schuler; A A Schäffer
Journal:  Genome Res       Date:  2000-03       Impact factor: 9.043
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