Literature DB >> 22182207

Trigocherrin A, the first natural chlorinated daphnane diterpene orthoester from Trigonostemon cherrieri.

Pierre-Marie Allard1, Marie-Thérèse Martin, Marie-Elise Tran Huu Dau, Pieter Leyssen, Françoise Guéritte, Marc Litaudon.   

Abstract

Trigocherrin A, a chlorinated and highly oxygenated daphnane diterpenoid orthoester (DDO), was isolated from the bark of Trigonostemon cherrieri. Trigocherrin A is the first example of a naturally occurring halogenated DDO. Its structure was elucidated by comprehensive analysis of NMR spectroscopic data, and its absolute configuration was determined by comparison of experimental and theoretically calculated ECD spectra. Trigocherrin A exhibited a potent and selective effect against Chikungunya virus in Vero cells.
© 2011 American Chemical Society

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Year:  2011        PMID： 22182207     DOI： 10.1021/ol2030907

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

1.  Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway.

Authors:  Daryl Staveness; Rana Abdelnabi; Katherine E Near; Yu Nakagawa; Johan Neyts; Leen Delang; Pieter Leyssen; Paul A Wender
Journal:  J Nat Prod       Date:  2016-02-22       Impact factor: 4.050

Review 2.  The medicinal chemistry of Chikungunya virus.

Authors:  Edeildo F da Silva-Júnior; Giovanni O Leoncini; Érica E S Rodrigues; Thiago M Aquino; João X Araújo-Júnior
Journal:  Bioorg Med Chem       Date:  2017-06-29       Impact factor: 3.641

Review 3.  Current and Promising Antivirals Against Chikungunya Virus.

Authors:  Friederike I L Hucke; Joachim J Bugert
Journal:  Front Public Health       Date:  2020-12-15

4.  Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids.

Authors:  Jian Bai; Rong Mu; Man Dou; Daojiang Yan; Bingyu Liu; Qian Wei; Jun Wan; Yi Tang; Youcai Hu
Journal:  Acta Pharm Sin B       Date:  2018-02-21       Impact factor: 11.413

Review 5.  Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapy.

Authors:  Simon-Djamel Thiberville; Nanikaly Moyen; Laurence Dupuis-Maguiraga; Antoine Nougairede; Ernest A Gould; Pierre Roques; Xavier de Lamballerie
Journal:  Antiviral Res       Date:  2013-06-28       Impact factor: 5.970
  5 in total

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