PURPOSE: To show the diurnal variation of tear osmolarity in normal subjects. METHODS: Thirty volunteers were recruited. Tear osmolarity was measured with TearLab osmolarity system at 3-hour regular intervals between 8:00 am and 5:00 pm. One-way analysis of variance test was used for statistical analysis. RESULTS: Thirty healthy volunteers (all men) with a mean age of 29.6 ± 4.3 years (range 18-45) were recruited. The difference between measurements at 8:00 am and 11:00 am, 8:00 am and 2:00 pm, 8:00 am and 5:00 pm, 11:00 am and 2:00 pm, 11:00 am and 5:00 pm, and 2:00 pm and 5:00 pm were not statistically significant (one-way analysis of variance test, p>0.05). CONCLUSIONS: In normal subjects, tear osmolarity seems to have a stable profile during the daytime.
PURPOSE: To show the diurnal variation of tear osmolarity in normal subjects. METHODS: Thirty volunteers were recruited. Tear osmolarity was measured with TearLab osmolarity system at 3-hour regular intervals between 8:00 am and 5:00 pm. One-way analysis of variance test was used for statistical analysis. RESULTS: Thirty healthy volunteers (all men) with a mean age of 29.6 ± 4.3 years (range 18-45) were recruited. The difference between measurements at 8:00 am and 11:00 am, 8:00 am and 2:00 pm, 8:00 am and 5:00 pm, 11:00 am and 2:00 pm, 11:00 am and 5:00 pm, and 2:00 pm and 5:00 pm were not statistically significant (one-way analysis of variance test, p>0.05). CONCLUSIONS: In normal subjects, tear osmolarity seems to have a stable profile during the daytime.
Authors: Raied Fagehi; Abdulkareem B Al-Bishry; Mana A Alanazi; Ali Abusharha; Gamal A El-Hiti; Ali M Masmali Journal: Taiwan J Ophthalmol Date: 2020-12-17