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Literature DB >> 22178785

Metabolic and cardiovascular genes in polycystic ovary syndrome: a candidate-wide association study (CWAS).

Michelle R Jones¹, Angela K Chua, Emebet A Mengesha, Kent D Taylor, Yii-Der I Chen, Xiaohui Li, Ronald M Krauss, Jerome I Rotter, Richard S Legro, Ricardo Azziz, Mark O Goodarzi.

Abstract

The role of metabolic disturbance in polycystic ovary syndrome (PCOS) has been well established, with insulin resistance and the resulting compensatory hyperinsulinemia thought to promote hyperandrogenemia. Genome-wide association studies (GWAS) have established a large number of loci for metabolic conditions such as type 2 diabetes and obesity. A subset of these loci has been investigated for a role in PCOS; these studies generally have not revealed a confirmed role for these loci in PCOS risk. However, a large scale investigation of genes related to these pathways has not previously been performed. We conducted a two stage case control association study of 121,715 single nucleotide polymorphisms (SNPs) selected to represent susceptibility loci associated with traits such as type 2 diabetes, obesity measures, lipid levels and cardiovascular function using the Cardio-Metabochip in 847 PCOS cases and 845 controls. Several hypothesis-generating associations with PCOS were observed (top SNP rs2129107, P=3.8×10(-6)). We did not find any loci definitively associated with PCOS after strict correction for multiple testing, suggesting that cardio-metabolic loci are not major risk factors underlying the susceptibility to PCOS. Copyright Â

Entities: Chemical Disease Gene Mutation Species

Mesh：

Year: 2011 PMID： 22178785 PMCID： PMC3689580 DOI： 10.1016/j.steroids.2011.12.005

Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668

43 in total

Review 1. Whole-genome genotyping.

Authors: Kevin L Gunderson; Frank J Steemers; Hongi Ren; Pauline Ng; Lixin Zhou; Chan Tsan; Weihua Chang; Dave Bullis; Joe Musmacker; Christine King; Lori L Lebruska; David Barker; Arnold Oliphant; Kenneth M Kuhn; Richard Shen
Journal: Methods Enzymol Date: 2006 Impact factor: 1.600

2. PLINK: a tool set for whole-genome association and population-based linkage analyses.

Authors: Shaun Purcell; Benjamin Neale; Kathe Todd-Brown; Lori Thomas; Manuel A R Ferreira; David Bender; Julian Maller; Pamela Sklar; Paul I W de Bakker; Mark J Daly; Pak C Sham
Journal: Am J Hum Genet Date: 2007-07-25 Impact factor: 11.025

3. The Pregnancy in Polycystic Ovary Syndrome study: baseline characteristics of the randomized cohort including racial effects.

Authors: Richard S Legro; Evan R Myers; Huiman X Barnhart; Sandra A Carson; Michael P Diamond; Bruce R Carr; William D Schlaff; Christos Coutifaris; Peter G McGovern; Nicholas A Cataldo; Michael P Steinkampf; John E Nestler; Gabriella Gosman; Linda C Guidice; Phyllis C Leppert
Journal: Fertil Steril Date: 2006-09-11 Impact factor: 7.329

4. Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) Study.

Authors: Joel A Simon; Feng Lin; Stephen B Hulley; Patricia J Blanche; David Waters; Stephen Shiboski; Jerome I Rotter; Deborah A Nickerson; Huiying Yang; Mohammed Saad; Ronald M Krauss
Journal: Am J Cardiol Date: 2006-01-27 Impact factor: 2.778

5. Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndrome.

Authors: Pei Xu; Yena Che; Yunxia Cao; XiaoKe Wu; Haixiang Sun; Fengjing Liang; Jing Sun; Lu Ke; Long Yi; Yong Wang
Journal: J Assist Reprod Genet Date: 2009-12-30 Impact factor: 3.412

6. Postmenopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: results from the National Institutes of Health--National Heart, Lung, and Blood Institute sponsored Women's Ischemia Syndrome Evaluation.

Authors: Leslee J Shaw; C Noel Bairey Merz; Ricardo Azziz; Frank Z Stanczyk; George Sopko; Glenn D Braunstein; Sheryl F Kelsey; Kevin E Kip; Rhonda M Cooper-Dehoff; B Delia Johnson; Viola Vaccarino; Steven E Reis; Vera Bittner; T Keta Hodgson; William Rogers; Carl J Pepine
Journal: J Clin Endocrinol Metab Date: 2008-01-08 Impact factor: 5.958

7. Relationship between E23K (an established type II diabetes-susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels.

Authors: Thomas M Barber; Amanda J Bennett; Anna L Gloyn; Christopher J Groves; Ulla Sovio; Aimo Ruokonen; Hannu Martikainen; Anneli Pouta; Saara Taponen; Michael N Weedon; Anna-Liisa Hartikainen; John A H Wass; Marjo-Riitta Järvelin; Eleftheria Zeggini; Stephen Franks; Mark I McCarthy
Journal: Eur J Hum Genet Date: 2007-03-07 Impact factor: 4.246

8. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.

Authors: Eleftheria Zeggini; Michael N Weedon; Cecilia M Lindgren; Timothy M Frayling; Katherine S Elliott; Hana Lango; Nicholas J Timpson; John R B Perry; Nigel W Rayner; Rachel M Freathy; Jeffrey C Barrett; Beverley Shields; Andrew P Morris; Sian Ellard; Christopher J Groves; Lorna W Harries; Jonathan L Marchini; Katharine R Owen; Beatrice Knight; Lon R Cardon; Mark Walker; Graham A Hitman; Andrew D Morris; Alex S F Doney; Mark I McCarthy; Andrew T Hattersley
Journal: Science Date: 2007-04-26 Impact factor: 47.728

9. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Authors:
Journal: Nature Date: 2007-06-07 Impact factor: 49.962

10. Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS.

Authors: T M Barber; A J Bennett; C J Groves; U Sovio; A Ruokonen; H Martikainen; A Pouta; A-L Hartikainen; P Elliott; J A H Wass; M-R Järvelin; E Zeggini; S Franks; M I McCarthy
Journal: Diabetologia Date: 2007-09-06 Impact factor: 10.122

11 in total

1. Leutinizing hormone/choriogonadotropin receptor and follicle stimulating hormone receptor gene variants in polycystic ovary syndrome.

Authors: Wassim Y Almawi; Bayan Hubail; Dana Z Arekat; Suhaila M Al-Farsi; Shadha K Al-Kindi; Mona R Arekat; Naeema Mahmood; Samira Madan
Journal: J Assist Reprod Genet Date: 2015-02-04 Impact factor: 3.412

Review 2. Hyperandrogenic origins of polycystic ovary syndrome - implications for pathophysiology and therapy.

Authors: David H Abbott; Daniel A Dumesic; Jon E Levine
Journal: Expert Rev Endocrinol Metab Date: 2019-02-15

Review 3. Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome.

Authors: Elisabet Stener-Victorin; Vasantha Padmanabhan; Kirsty A Walters; Rebecca E Campbell; Anna Benrick; Paolo Giacobini; Daniel A Dumesic; David H Abbott
Journal: Endocr Rev Date: 2020-07-01 Impact factor: 19.871

Review 4. Association between rs7903146 and rs12255372 polymorphisms of transcription factor 7-like 2 gene and polycystic ovary syndrome: a systematic review and meta-analysis.

Authors: Ramon Bossardi Ramos; Vitor Costa Fabris; Letícia de Almeida Brondani; Poli Mara Spritzer
Journal: Endocrine Date: 2015-02-13 Impact factor: 3.633

5. Further investigation in europeans of susceptibility variants for polycystic ovary syndrome discovered in genome-wide association studies of Chinese individuals.

Authors: Meredith A Brower; Michelle R Jones; Jerome I Rotter; Ronald M Krauss; Richard S Legro; Ricardo Azziz; Mark O Goodarzi
Journal: J Clin Endocrinol Metab Date: 2015-01 Impact factor: 5.958

6. Bidirectional Mendelian randomization to explore the causal relationships between body mass index and polycystic ovary syndrome.

Authors: M A Brower; Y Hai; M R Jones; X Guo; Y-D I Chen; J I Rotter; R M Krauss; R S Legro; R Azziz; M O Goodarzi
Journal: Hum Reprod Date: 2019-01-01 Impact factor: 6.918