OBJECTIVE: To examine prevalence, characteristics, interventions, and mortality of very low birth weight (VLBW) infants with trisomy 21 (T21), trisomy 18 (T18), trisomy 13 (T13), or triploidy. STUDY DESIGN: Infants with birth weight 401-1500 g admitted to centers of the Vermont Oxford Network during 1994-2009 were studied. A majority of the analyses are presented as descriptive data. Median survival times and their 95% CIs were estimated using the Kaplan-Meier approach. RESULTS: Of 539 509 VLBW infants, 1681 (0.31%) were diagnosed with T21, 1416 (0.26%) with T18, 435 (0.08%) with T13, and 116 (0.02%) with triploidy. Infants with T18 were the most likely to be growth restricted (79.7%). Major surgery was reported for 30.4% of infants with T21, 9.2% with T18, 6.4% with T13, and 4.8% with triploidy. Hospital mortality occurred among 33.1% of infants with T21, 89.0% with T18, 92.4% with T13, and 90.5% with triploidy. Median survival time was 4 days (95% CI, 3-4) among infants with T18 and 3 days (95% CI, 2-4) among both infants with T13 and infants with triploidy. CONCLUSION: In this cohort of VLBW infants, survival among infants with T18, T13, or triploidy was very poor. This information can be used to counsel families.
OBJECTIVE: To examine prevalence, characteristics, interventions, and mortality of very low birth weight (VLBW) infants with trisomy 21 (T21), trisomy 18 (T18), trisomy 13 (T13), or triploidy. STUDY DESIGN:Infants with birth weight 401-1500 g admitted to centers of the Vermont Oxford Network during 1994-2009 were studied. A majority of the analyses are presented as descriptive data. Median survival times and their 95% CIs were estimated using the Kaplan-Meier approach. RESULTS: Of 539 509 VLBW infants, 1681 (0.31%) were diagnosed with T21, 1416 (0.26%) with T18, 435 (0.08%) with T13, and 116 (0.02%) with triploidy. Infants with T18 were the most likely to be growth restricted (79.7%). Major surgery was reported for 30.4% of infants with T21, 9.2% with T18, 6.4% with T13, and 4.8% with triploidy. Hospital mortality occurred among 33.1% of infants with T21, 89.0% with T18, 92.4% with T13, and 90.5% with triploidy. Median survival time was 4 days (95% CI, 3-4) among infants with T18 and 3 days (95% CI, 2-4) among both infants with T13 and infants with triploidy. CONCLUSION: In this cohort of VLBW infants, survival among infants with T18, T13, or triploidy was very poor. This information can be used to counsel families.
Authors: Ira Adams-Chapman; Nellie I Hansen; Seetha Shankaran; Edward F Bell; Nansi S Boghossian; Jeffrey C Murray; Abbot R Laptook; Michele C Walsh; Waldemar A Carlo; Pablo J Sánchez; Krisa P Van Meurs; Abhik Das; Ellen C Hale; Nancy S Newman; M Bethany Ball; Rosemary D Higgins; Barbara J Stoll Journal: Pediatrics Date: 2013-06-03 Impact factor: 7.124
Authors: Nansi S Boghossian; Robert J Sicko; Denise M Kay; Shannon L Rigler; Michele Caggana; Michael Y Tsai; Edwina H Yeung; Nathan Pankratz; Benjamin R Cole; Charlotte M Druschel; Paul A Romitti; Marilyn L Browne; Ruzong Fan; Aiyi Liu; Lawrence C Brody; James L Mills Journal: Am J Med Genet A Date: 2015-12-14 Impact factor: 2.802
Authors: Alicia Vakalopoulos; Shyamali C Dharmage; Samath Dharmaratne; Pasan Jayasinghe; Olivia Lall; Isabella Ambrose; Rohan Weerasooriya; Dinh S Bui; Duminda Yasaratne; Jane Heyworth; Gayan Bowatte Journal: Int J Environ Res Public Health Date: 2021-02-15 Impact factor: 3.390
Authors: Nansi S Boghossian; Nellie I Hansen; Edward F Bell; Barbara J Stoll; Jeffrey C Murray; John C Carey; Ira Adams-Chapman; Seetha Shankaran; Michele C Walsh; Abbot R Laptook; Roger G Faix; Nancy S Newman; Ellen C Hale; Abhik Das; Leslie D Wilson; Angelita M Hensman; Cathy Grisby; Monica V Collins; Diana M Vasil; Joanne Finkle; Deanna Maffett; M Bethany Ball; Conra B Lacy; Rebecca Bara; Rosemary D Higgins Journal: Pediatrics Date: 2014-01-20 Impact factor: 7.124