Literature DB >> 29795453

NICU management and outcomes of infants with trisomy 21 without major anomalies.

Sarah McAndrew1, Krishna Acharya1, T Hang Nghiem-Rao1, Steven Leuthner1, Reese Clark2, Joanne Lagatta3.   

Abstract

OBJECTIVE: To describe how trisomy 21 affects neonatal intensive care management and outcomes of full-term infants without congenital anomalies. STUDY
DESIGN: Retrospective cohort of full-term infants without anomalies with and without trisomy 21 admitted to Pediatrix NICUs from 2005 to 2012. We compared diagnoses, management, length of stay, and discharge outcomes.
RESULTS: In all, 4623 infants with trisomy 21 and 606 770 infants without trisomy 21 were identified. One-third of infants in the NICU with and without trisomy 21 were full term without major anomalies. Trisomy 21 infants had more respiratory distress, thrombocytopenia, feeding problems, and pulmonary hypertension. They received respiratory support for a longer period of time and had a longer length of stay.
CONCLUSION: One-third of infants with trisomy 21 admitted to the NICU are full term without major anomalies. Common diagnoses and greater respiratory needs place infants with trisomy 21 at risk for longer length of stay.

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Mesh:

Year:  2018        PMID: 29795453      PMCID: PMC6335104          DOI: 10.1038/s41372-018-0136-5

Source DB:  PubMed          Journal:  J Perinatol        ISSN: 0743-8346            Impact factor:   2.521


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2.  Increased incidence of idiopathic persistent pulmonary hypertension in Down syndrome neonates.

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3.  Major anomalies and birth-weight influence NICU interventions and mortality in infants with trisomy 13 or 18.

Authors:  K Acharya; S Leuthner; R Clark; T H Nghiem-Rao; A Spitzer; J Lagatta
Journal:  J Perinatol       Date:  2017-01-12       Impact factor: 2.521

4.  Major congenital anomalies in babies born with Down syndrome: a EUROCAT population-based registry study.

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Journal:  Am J Med Genet A       Date:  2014-09-24       Impact factor: 2.802

5.  Infants Born with Down Syndrome: Burden of Disease in the Early Neonatal Period.

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6.  Health supervision for children with Down syndrome.

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Journal:  Pediatrics       Date:  2011-07-25       Impact factor: 7.124

7.  Mothers of children with Down syndrome reflect on their postnatal support.

Authors:  Brian Skotko
Journal:  Pediatrics       Date:  2005-01       Impact factor: 7.124

8.  Clinical characteristics and follow up of Down syndrome infants without congenital heart disease who presented with persistent pulmonary hypertension of newborn.

Authors:  Prakesh S Shah; Jonathan Hellmann; Ian Adatia
Journal:  J Perinat Med       Date:  2004       Impact factor: 1.901

9.  Ten-year review of major birth defects in VLBW infants.

Authors:  Ira Adams-Chapman; Nellie I Hansen; Seetha Shankaran; Edward F Bell; Nansi S Boghossian; Jeffrey C Murray; Abbot R Laptook; Michele C Walsh; Waldemar A Carlo; Pablo J Sánchez; Krisa P Van Meurs; Abhik Das; Ellen C Hale; Nancy S Newman; M Bethany Ball; Rosemary D Higgins; Barbara J Stoll
Journal:  Pediatrics       Date:  2013-06-03       Impact factor: 7.124

10.  Anomalies in Down syndrome individuals in a large population-based registry.

Authors:  C P Torfs; R E Christianson
Journal:  Am J Med Genet       Date:  1998-06-05
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  2 in total

1.  Morbidity and mortality in neonates with Down Syndrome based on gestational age.

Authors:  Emily A Messick; Carl H Backes; Kenneth Jackson; Sara Conroy; Stephen A Hart; Clifford L Cua
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Review 2.  Feeding Problems and Long-Term Outcomes in Preterm Infants-A Systematic Approach to Evaluation and Management.

Authors:  Ranjith Kamity; Prasanna K Kapavarapu; Amit Chandel
Journal:  Children (Basel)       Date:  2021-12-08
  2 in total

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