BACKGROUND: Silicon (Si), as Si(OH)(4), is derived mainly from plant-based foods. Dietary Si is associated with bone mineral density (BMD) in premenopausal but not postmenopausal women. OBJECTIVE: To examine the association between Si intake and markers of bone health in middle-aged women and to test for interaction with oestrogen status. METHODS: Femoral neck (FN) and lumbar spine (LS) BMD, urinary markers of bone resorption (free pyridinoline and deoxypyridinoline cross-links relative to creatinine, fPYD/Cr and fDPD/Cr) and serum markers of bone formation (N-terminal propeptide of type 1 collagen, P1NP) were measured in a cohort of 3198 women aged 50-62 years (n=1170 current HRT users, n=1018 never used HRT). Dietary Si, bioavailable Si and dietary confounders were estimated by food frequency questionnaire. RESULTS: Mean FN BMD was 2% lower (p<0.005) in the lowest quartile (Q1) compared to the top quartile of energy-adjusted Si intake (Q4) (mean (SD) Q1, 16 (4.0) mg/d; Q4, 31.5 (7.3) mg/d). Energy-adjusted Si intake was associated with FN BMD for oestrogen-replete women only (late premenopausal women (r=+0.21, p=0.03); women on HRT [r=+0.09, p<0.001]). There was an interaction between oestrogen status and quartile of energy-adjusted Si intake on FN BMD, which was significant after adjustment for confounders (F=3.3, p=0.020), and stronger for bioavailable Si (F=5.0. p=0.002). Quartile of energy-adjusted dietary Si intake was negatively associated with fDPD/Cr and fPYD/Cr (p<0.001) and positively with P1NP (p<0.05). CONCLUSIONS: This study suggests that oestrogen status is important for Si metabolism in bone health. Further work is required to elucidate the mechanism. Copyright Â
BACKGROUND: Silicon (Si), as Si(OH)(4), is derived mainly from plant-based foods. Dietary Si is associated with bone mineral density (BMD) in premenopausal but not postmenopausal women. OBJECTIVE: To examine the association between Si intake and markers of bone health in middle-aged women and to test for interaction with oestrogen status. METHODS: Femoral neck (FN) and lumbar spine (LS) BMD, urinary markers of bone resorption (free pyridinoline and deoxypyridinoline cross-links relative to creatinine, fPYD/Cr and fDPD/Cr) and serum markers of bone formation (N-terminal propeptide of type 1 collagen, P1NP) were measured in a cohort of 3198 women aged 50-62 years (n=1170 current HRT users, n=1018 never used HRT). Dietary Si, bioavailable Si and dietary confounders were estimated by food frequency questionnaire. RESULTS: Mean FN BMD was 2% lower (p<0.005) in the lowest quartile (Q1) compared to the top quartile of energy-adjusted Si intake (Q4) (mean (SD) Q1, 16 (4.0) mg/d; Q4, 31.5 (7.3) mg/d). Energy-adjusted Si intake was associated with FN BMD for oestrogen-replete women only (late premenopausal women (r=+0.21, p=0.03); women on HRT [r=+0.09, p<0.001]). There was an interaction between oestrogen status and quartile of energy-adjusted Si intake on FN BMD, which was significant after adjustment for confounders (F=3.3, p=0.020), and stronger for bioavailable Si (F=5.0. p=0.002). Quartile of energy-adjusted dietary Si intake was negatively associated with fDPD/Cr and fPYD/Cr (p<0.001) and positively with P1NP (p<0.05). CONCLUSIONS: This study suggests that oestrogen status is important for Si metabolism in bone health. Further work is required to elucidate the mechanism. Copyright Â
Authors: Marcin R Tatara; Witold Krupski; Maria Szpetnar; Andrzej Dąbrowski; Paweł Bury; Anna Szabelska; Anna Charuta; Anna Boguszewska-Czubara; Ryszard Maciejewski; Grzegorz Wallner Journal: Exp Biol Med (Maywood) Date: 2015-06-02
Authors: Kai Jiao; Li-na Niu; Qi-hong Li; Fa-ming Chen; Wei Zhao; Jun-jie Li; Ji-hua Chen; Christopher W Cutler; David H Pashley; Franklin R Tay Journal: Acta Biomater Date: 2015-03-16 Impact factor: 8.947
Authors: Ravin Jugdaohsingh; Maio Hui; Simon Hc Anderson; Stephen D Kinrade; Jonathan J Powell Journal: Nutr Metab (Lond) Date: 2013-04-26 Impact factor: 4.169