PURPOSE: To develop a magnetic resonance imaging (MRI) sequence (fluid and white matter suppression, FLAWS) for generating two sets of images from a single acquisition: one with contrast similar to a T1-weighted magnetization-prepared rapid gradient-echo sequence (MPRAGE) for structural definition; the other with nulled white matter (WM) signal intensity, similar to the fast gray matter T1 inversion recovery (FGATIR) sequence, for improved delineation of subcortical brain structures. MATERIALS AND METHODS: The recently proposed MP2RAGE, which is a modification of the MPRAGE and generates two image sets at different inversion times, was employed to generate the FGATIR-like contrast (FLAWS1) and MPRAGE-like contrast (FLAWS2). Five healthy volunteers were scanned at 3T and brain tissue contrast and contrast-to-noise were compared. RESULTS: FLAWS1 and FLAWS2 exhibited similar tissue contrast and contrast-to-noise as the "reference" sequences, FGATIR and MPRAGE, respectively. Synthetic minimum value images generated from FLAWS1 and FLAWS2 provided a gray matter-dominant image. CONCLUSION: FLAWS provides two coregistered 3D volumes, one with nulled WM signal intensity and another with nulled cerebrospinal fluid. The coregistered nature of the two datasets allows for generating images that might be helpful in segmentation algorithms and clinical diagnosis.
PURPOSE: To develop a magnetic resonance imaging (MRI) sequence (fluid and white matter suppression, FLAWS) for generating two sets of images from a single acquisition: one with contrast similar to a T1-weighted magnetization-prepared rapid gradient-echo sequence (MPRAGE) for structural definition; the other with nulled white matter (WM) signal intensity, similar to the fast gray matter T1 inversion recovery (FGATIR) sequence, for improved delineation of subcortical brain structures. MATERIALS AND METHODS: The recently proposed MP2RAGE, which is a modification of the MPRAGE and generates two image sets at different inversion times, was employed to generate the FGATIR-like contrast (FLAWS1) and MPRAGE-like contrast (FLAWS2). Five healthy volunteers were scanned at 3T and brain tissue contrast and contrast-to-noise were compared. RESULTS: FLAWS1 and FLAWS2 exhibited similar tissue contrast and contrast-to-noise as the "reference" sequences, FGATIR and MPRAGE, respectively. Synthetic minimum value images generated from FLAWS1 and FLAWS2 provided a gray matter-dominant image. CONCLUSION: FLAWS provides two coregistered 3D volumes, one with nulled WM signal intensity and another with nulled cerebrospinal fluid. The coregistered nature of the two datasets allows for generating images that might be helpful in segmentation algorithms and clinical diagnosis.
Authors: Mauro Costagli; Douglas A C Kelley; Mark R Symms; Laura Biagi; Riccardo Stara; Eleonora Maggioni; Gianluigi Tiberi; Carmen Barba; Renzo Guerrini; Mirco Cosottini; Michela Tosetti Journal: Neuroradiology Date: 2014-04-25 Impact factor: 2.804
Authors: Ya-Jun Ma; Shujuan Fan; Hongda Shao; Jiang Du; Nikolaus M Szeverenyi; Ian R Young; Graeme M Bydder Journal: Quant Imaging Med Surg Date: 2020-06
Authors: Masaya Misaki; Jonathan Savitz; Vadim Zotev; Raquel Phillips; Han Yuan; Kymberly D Young; Wayne C Drevets; Jerzy Bodurka Journal: Magn Reson Med Date: 2014-12-22 Impact factor: 4.668
Authors: Herwin Speckter; José Bido; Giancarlo Hernandez; Diones Rivera; Luis Suazo; Santiago Valenzuela; Rafael Fermin; Jairo Oviedo; Bernd Foerster; Cesar Gonzalez; Peter Stoeter Journal: J Radiosurg SBRT Date: 2018