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Literature DB >> 22170192

Safety of azathioprine use during pregnancy.

Aniket Natekar¹, Anna Pupco, Pina Bozzo, Gideon Koren.
1. University of Toronto.

Abstract

QUESTION: Quite a few of my female patients with rheumatic diseases and inflammatory bowel disease are using azathioprine. They are afraid to take a "cancer drug" during pregnancy. What is known about the risks? ANSWER: An increasing body of evidence from prospective cohort studies suggests that azathioprine is safe for the fetus during pregnancy.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2011 PMID： 22170192 PMCID： PMC3237512

Source DB: PubMed Journal: Can Fam Physician ISSN： 0008-350X Impact factor: 3.275

15 in total

1. Teratology Society 51st Annual Meeting, June 25-29, 2011, Coronado, California, USA. Abstracts.

Authors:
Journal: Birth Defects Res A Clin Mol Teratol Date: 2011-05

2. Is immunosuppression therapy in renal allograft recipients teratogenic? A single-center experience.

Authors: Jacob Bar; Bracha Stahl; Moshe Hod; Clara Wittenberg; Joseph Pardo; Paul Merlob
Journal: Am J Med Genet A Date: 2003-01-01 Impact factor: 2.802

3. Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.

Authors: T Dervieux; J G Blanco; E Y Krynetski; E F Vanin; M F Roussel; M V Relling
Journal: Cancer Res Date: 2001-08-01 Impact factor: 12.701

4. Factors associated with fetal losses in severe systemic lupus erythematosus.

Authors: J O Martínez-Rueda; C A Arce-Salinas; A Kraus; J Alcocer-Varela; D Alarcón-Segovia
Journal: Lupus Date: 1996-04 Impact factor: 2.911

5. Azathioprine, mercaptopurine and birth outcome: a population-based cohort study.

Authors: B Nørgård; L Pedersen; K Fonager; S N Rasmussen; H T Sørensen
Journal: Aliment Pharmacol Ther Date: 2003-03-15 Impact factor: 8.171

6. Early pregnancy azathioprine use and pregnancy outcomes.

Authors: Brian J Cleary; Bengt Källén
Journal: Birth Defects Res A Clin Mol Teratol Date: 2009-07

7. Pregnancy in autoimmune hepatitis: outcome and risk factors.

Authors: Christoph Schramm; Johannes Herkel; Ulrich Beuers; Stephan Kanzler; Peter R Galle; Ansgar W Lohse
Journal: Am J Gastroenterol Date: 2006-02-08 Impact factor: 10.864

8. The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs.

Authors: Sally A Coulthard; Linda A Hogarth; Margaret Little; Elizabeth C Matheson; Christopher P F Redfern; Lynne Minto; Andrew G Hall
Journal: Mol Pharmacol Date: 2002-07 Impact factor: 4.436

9. Pregnancy outcome of women exposed to azathioprine during pregnancy.

Authors: Lee Hilary Goldstein; Galit Dolinsky; Revital Greenberg; Christof Schaefer; Raanan Cohen-Kerem; Orna Diav-Citrin; Heli Malm; Minke E Reuvers-Lodewijks; Margreet M Rost van Tonningen-van Driel; Judith Arnon; Asher Ornoy; Maurizio Clementi; Elena Di Gianantonio; Gideon Koren; Rony Braunstein; Matitiahu Berkovitch
Journal: Birth Defects Res A Clin Mol Teratol Date: 2007-10

Review 10. Clinical pharmacology and pharmacogenetics of thiopurines.

Authors: Srikumar Sahasranaman; Danny Howard; Sandip Roy
Journal: Eur J Clin Pharmacol Date: 2008-05-28 Impact factor: 3.064

11 in total

1. Granulomatosis with polyangiitis and pregnancy: A case report and review of the literature.

Authors: A Daher; G Sauvetre; N Girszyn; E Verspyck; H Levesque; M Le Besnerais
Journal: Obstet Med Date: 2019-03-16

2. Updated international consensus report on the investigation and management of primary immune thrombocytopenia.

Authors: Drew Provan; Donald M Arnold; James B Bussel; Beng H Chong; Nichola Cooper; Terry Gernsheimer; Waleed Ghanima; Bertrand Godeau; Tomás José González-López; John Grainger; Ming Hou; Caroline Kruse; Vickie McDonald; Marc Michel; Adrian C Newland; Sue Pavord; Francesco Rodeghiero; Marie Scully; Yoshiaki Tomiyama; Raymond S Wong; Francesco Zaja; David J Kuter
Journal: Blood Adv Date: 2019-11-26

Safety of azathioprine use during pregnancy.

1. Teratology Society 51st Annual Meeting, June 25-29, 2011, Coronado, California, USA. Abstracts.

2. Is immunosuppression therapy in renal allograft recipients teratogenic? A single-center experience.

3. Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.

4. Factors associated with fetal losses in severe systemic lupus erythematosus.

5. Azathioprine, mercaptopurine and birth outcome: a population-based cohort study.

6. Early pregnancy azathioprine use and pregnancy outcomes.

7. Pregnancy in autoimmune hepatitis: outcome and risk factors.

8. The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs.

9. Pregnancy outcome of women exposed to azathioprine during pregnancy.

Review 10. Clinical pharmacology and pharmacogenetics of thiopurines.

1. Granulomatosis with polyangiitis and pregnancy: A case report and review of the literature.

2. Updated international consensus report on the investigation and management of primary immune thrombocytopenia.

3. Antiproliferatives and Transplantation.

Review 4. Treatment of Myasthenia Gravis in the Aged.

Review 5. Neuromyelitis optica spectrum disorders and pregnancy: therapeutic considerations.

6. Ultrasound Presentation of a Disseminated Fetal and Neonatal Rhabdoid Tumor.

7. A Systematic Review of Treatment Options and Clinical Outcomes in Pemphigoid Gestationis.

8. Diagnostic Ideas and Management Strategies for Thrombocytopenia of Unknown Causes in Pregnancy.

9. Systematic review with meta-analysis: outcomes of pregnancy in patients with autoimmune hepatitis.

Review 10. Rheumatologic Medication Use During Pregnancy.