OBJECTIVE: To test the effect of raising ambient temperature (AT) on activity-based anorexia (ABA) and to extend to female rats previous findings reported in male animals. METHOD: Two studies are reported in which female rats were submitted to food restriction and free access to an activity wheel either separately or in combination under changing (21-32 °C) or constant AT (21 °C). RESULTS: Warming ABA animals reversed running activity, preserved food-intake, and enabled female rats to recover from acute weight loss. Moreover, sedentary food-restricted warmed rats maintained a body weight equivalent to the levels of animals housed at standard AT in spite of 20% reduced food-intake. DISCUSSION: The replication on female rats corroborates the effect previously reported for males, which is indicative of the robust effect of AT in recovering rats from ABA. The findings reported here represent strong preclinical evidence in favor of heat supply as a useful adjunctive component for the treatment of anorexia nervosa (AN).
OBJECTIVE: To test the effect of raising ambient temperature (AT) on activity-based anorexia (ABA) and to extend to female rats previous findings reported in male animals. METHOD: Two studies are reported in which female rats were submitted to food restriction and free access to an activity wheel either separately or in combination under changing (21-32 °C) or constant AT (21 °C). RESULTS: Warming ABA animals reversed running activity, preserved food-intake, and enabled female rats to recover from acute weight loss. Moreover, sedentary food-restricted warmed rats maintained a body weight equivalent to the levels of animals housed at standard AT in spite of 20% reduced food-intake. DISCUSSION: The replication on female rats corroborates the effect previously reported for males, which is indicative of the robust effect of AT in recovering rats from ABA. The findings reported here represent strong preclinical evidence in favor of heat supply as a useful adjunctive component for the treatment of anorexia nervosa (AN).
Authors: Angela Fraga; Eva Rial-Pensado; Rubén Nogueiras; Johan Fernø; Carlos Diéguez; Emilio Gutierrez; Miguel López Journal: Front Endocrinol (Lausanne) Date: 2021-06-02 Impact factor: 5.555
Authors: Olaia Carrera; Roger A H Adan; Emilio Gutierrez; Unna N Danner; Hans W Hoek; Annemarie A van Elburg; Martien J H Kas Journal: PLoS One Date: 2012-07-27 Impact factor: 3.240
Authors: David R Kolar; Katharina Bühren; Beate Herpertz-Dahlmann; Katja Becker; Karin Egberts; Stefan Ehrlich; Christian Fleischhaker; Alexander von Gontard; Freia Hahn; Michael Huss; Charlotte Jaite; Michael Kaess; Tanja Legenbauer; Tobias J Renner; Veit Roessner; Ulrike Schulze; Judith Sinzig; Ida Wessing; Johannes Hebebrand; Manuel Föcker; Ekkehart Jenetzky Journal: PLoS One Date: 2018-09-11 Impact factor: 3.240