| Literature DB >> 221698 |
J B Rooks, H W Ory, K G Ishak, L T Strauss, J R Greenspan, A P Hill, C W Tyler.
Abstract
A case-control study of hepatocellular adenoma (HCA), a serious though nonmalignant liver tumor, was conducted by the Center for Disease Control and the Armed Forces Institute of Pathology (AFIP). Interviews with 79 women with HCA and with 220 age- and neighborhood-matched controls were completed. Limited information was obtained on nine additional patients who had died. Women with HCA and hemorrhage have a greater risk of morbidity and death than those with other symptoms. Increasing duration of OC use increases the risk of HCA. Use of OCs with high hormonal potency and age over 30 years may further increase a woman's risk of HCA. Long-term users of OCs have an estimated annual incidence of HCA of 3 to 4 per 100,000.Entities:
Keywords: Americas; Biology; Bleeding; Contraception; Contraceptive Methods--contraindications; Developed Countries; Family Planning; Genetics; Hepatic Effects; Mortality; North America; Northern America; Oral Contraceptives--contraindications; Physiology; Research Methodology; Retrospective Studies; Studies; United States; Women
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Year: 1979 PMID： 221698
Source DB: PubMed Journal: JAMA ISSN： 0098-7484 Impact factor: 56.272