| Literature DB >> 22169337 |
Michael Croft1, Wei Duan, Heonsik Choi, So-Young Eun, Shravan Madireddi, Amit Mehta.
Abstract
The tumor necrosis factor (TNF) and TNF receptor superfamilies (TNFSF and TNFRSF) consist of approximately 50 membrane and soluble proteins that can modulate cellular function. Most of these molecules are expressed by or can target cells of the immune system, and they have a wide range of actions including promoting cellular differentiation, survival, and production of inflammatory cytokines and chemokines. Emerging data show that TNFSF ligand-receptor signaling pathways are active in inflammatory and autoimmune disease. Furthermore, several genetic polymorphisms in TNFSF and TNFRSF associate with susceptibility to developing disease. Here, we examine recent data regarding the potential of these molecules as targets for therapy of autoimmune and inflammatory disease. Copyright ÂEntities:
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Year: 2011 PMID： 22169337 PMCID： PMC3299395 DOI： 10.1016/j.it.2011.10.004
Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687