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Literature DB >> 26008591

Regulation of tumour necrosis factor signalling: live or let die.

Dirk Brenner¹, Heiko Blaser², Tak W Mak³.

Abstract

Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has important roles in mammalian immunity and cellular homeostasis. Deregulation of TNF receptor (TNFR) signalling is associated with many inflammatory disorders, including various types of arthritis and inflammatory bowel disease, and targeting TNF has been an effective therapeutic strategy in these diseases. This Review focuses on the recent advances that have been made in understanding TNFR signalling and the consequences of its deregulation for cellular survival, apoptosis and regulated necrosis. We discuss how TNF-induced survival signals are distinguished from those that lead to cell death. Finally, we provide a brief overview of the role of TNF in inflammatory and autoimmune diseases, and we discuss up-to-date and future treatment strategies for these disorders.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2015 PMID： 26008591 DOI： 10.1038/nri3834

Source DB: PubMed Journal: Nat Rev Immunol ISSN： 1474-1733 Impact factor: 53.106

177 in total

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Journal: Nature Date: 1997-02-20 Impact factor: 49.962

3. Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation.

Authors: D J Mahoney; H H Cheung; R Lejmi Mrad; S Plenchette; C Simard; E Enwere; V Arora; T W Mak; E C Lacasse; J Waring; R G Korneluk
Journal: Proc Natl Acad Sci U S A Date: 2008-08-12 Impact factor: 11.205

4. Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis.

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5. Structural basis for the lack of E2 interaction in the RING domain of TRAF2.

Authors: Qian Yin; Betty Lamothe; Bryant G Darnay; Hao Wu
Journal: Biochemistry Date: 2009-11-10 Impact factor: 3.162

6. RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition.

Authors: William J Kaiser; Lisa P Daley-Bauer; Roshan J Thapa; Pratyusha Mandal; Scott B Berger; Chunzi Huang; Aarthi Sundararajan; Hongyan Guo; Linda Roback; Samuel H Speck; John Bertin; Peter J Gough; Siddharth Balachandran; Edward S Mocarski
Journal: Proc Natl Acad Sci U S A Date: 2014-05-12 Impact factor: 11.205

7. The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors.

Authors: Yelena L Pobezinskaya; You-Sun Kim; Swati Choksi; Michael J Morgan; Tao Li; Chengyu Liu; Zhenggang Liu
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8. Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

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Journal: Nature Date: 2012-08-23 Impact factor: 49.962

10. Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

Authors: Brian J Zarnegar; Yaya Wang; Douglas J Mahoney; Paul W Dempsey; Herman H Cheung; Jeannie He; Travis Shiba; Xiaolu Yang; Wen-Chen Yeh; Tak W Mak; Robert G Korneluk; Genhong Cheng
Journal: Nat Immunol Date: 2008-11-09 Impact factor: 25.606

305 in total

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Authors: Shrikant R Mulay; Andreas Linkermann; Hans-Joachim Anders
Journal: J Am Soc Nephrol Date: 2015-09-02 Impact factor: 10.121

2. TNFα in liver fibrosis.

Authors: Yoon Mee Yang; Ekihiro Seki
Journal: Curr Pathobiol Rep Date: 2015-09-30

Review 3. Necroptosis: A new way of dying?

Authors: Britt Hanson
Journal: Cancer Biol Ther Date: 2016-07-19 Impact factor: 4.742

4. Herpes simplex virus 1 ICP6 impedes TNF receptor 1-induced necrosome assembly during compartmentalization to detergent-resistant membrane vesicles.

Authors: Mohammad Ali; Linda Roback; Edward S Mocarski
Journal: J Biol Chem Date: 2018-11-30 Impact factor: 5.157

5. TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.

Authors: Masayuki Yamashita; Emmanuelle Passegué
Journal: Cell Stem Cell Date: 2019-06-20 Impact factor: 24.633

6. Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation.

Authors: Andrew T Templin; Tanya Samarasekera; Daniel T Meier; Meghan F Hogan; Mahnaz Mellati; Michael T Crow; Richard N Kitsis; Sakeneh Zraika; Rebecca L Hull; Steven E Kahn
Journal: Diabetes Date: 2017-07-20 Impact factor: 9.461