| Literature DB >> 22169259 |
Thaís Moreira Osório1, Franco Delle Monache, Louise Domeneghini Chiaradia, Alessandra Mascarello, Taisa Regina Stumpf, Carlos Roberto Zanetti, Douglas Bardini Silveira, Célia Regina Monte Barardi, Elza de Fatima Albino Smânia, Aline Viancelli, Lucas Ariel Totaro Garcia, Rosendo Augusto Yunes, Ricardo José Nunes, Artur Smânia.
Abstract
The increase in antibiotic resistance due to multiple factors has encouraged the search for new compounds which are active against multidrug-resistant pathogens. In this context, chalcones, dihydrochalcones, hydrazones and oxadiazoles were tested against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus (MRSA) isolates, which were obtained from clinical laboratories and were characterized as MRSA using traditional and molecular methods. Among 65 tested compounds, two chalcones, one dihydrochalcone and two hydrazones were active against MRSA. Based on the minimal inhibitory concentration and cytotoxicity, hydrazones provided a better selectivity index than chalcones. Active hydrazones are promising antibiotic-like substances and they should be the subject of further microbiological studies.Entities:
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Year: 2011 PMID： 22169259 DOI： 10.1016/j.bmcl.2011.11.059
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823