| Literature DB >> 22169097 |
Hanshao Liu1, Lin Zhu, Bingya Liu, Liu Yang, Xianxin Meng, Wei Zhang, Yueyun Ma, Huasheng Xiao.
Abstract
Recent studies demonstrated that in several human malignancies aberrant expression profiles of circulating microRNAs (miRNAs) anticipate great cancer diagnostic potential. Here we showed that serum miR-378 could serve as a novel noninvasive biomarker in gastric cancer (GC) detection. Genome-wide miRNA expression profiles followed with Real-Time quantitative RT-PCR (qRT-PCR) assays revealed that miR-187(*), miR-371-5p and miR-378 were significantly elevated in GC patients. Further validation indicated that miR-378 alone could yields a ROC curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating GC patients from healthy controls. Collectively, these data support our contention that serum miR-378 has strong potential as a novel noninvasive biomarker in gastric cancer detection.Entities:
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Year: 2011 PMID： 22169097 DOI： 10.1016/j.canlet.2011.10.034
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679