PURPOSE: Axillary lymph node dissection (ALND) remains the standard procedure for breast cancer patients with sentinel lymph node (SLN) metastasis; however, additional nodal metastasis is detected in completion ALND in only about 50% of these patients. To identify the risk of non-SLN metastasis, the Memorial Sloan-Kettering Cancer Center (MSKCC) developed a nomogram. Many validation studies have been performed to evaluate the accuracy of the nomogram in Western populations, but not in Asians. We conducted this study to establish the accuracy of the nomogram in a Japanese population. METHODS: The accuracy of the MSKCC nomogram for predicting non-SLN status was tested in 116 consecutive SLN-positive patients in our hospital. We then compared the findings of the source MSKCC study with those of our study. A receiver operating characteristics (ROC) curve was plotted, and the area under the curve (AUC) was calculated to assess the discriminative power. RESULTS: Despite the differences between our patients and the source population in many respects, the area under the ROC curve was 0.73, which was comparable to that obtained in the study on the source population. CONCLUSIONS: The MSKCC nomogram provides a fairly accurate predicted probability for the likelihood of non-SLN metastases. Accordingly, it served as a useful tool for our Japanese patients with SLN metastases.
PURPOSE: Axillary lymph node dissection (ALND) remains the standard procedure for breast cancerpatients with sentinel lymph node (SLN) metastasis; however, additional nodal metastasis is detected in completion ALND in only about 50% of these patients. To identify the risk of non-SLN metastasis, the Memorial Sloan-Kettering Cancer Center (MSKCC) developed a nomogram. Many validation studies have been performed to evaluate the accuracy of the nomogram in Western populations, but not in Asians. We conducted this study to establish the accuracy of the nomogram in a Japanese population. METHODS: The accuracy of the MSKCC nomogram for predicting non-SLN status was tested in 116 consecutive SLN-positive patients in our hospital. We then compared the findings of the source MSKCC study with those of our study. A receiver operating characteristics (ROC) curve was plotted, and the area under the curve (AUC) was calculated to assess the discriminative power. RESULTS: Despite the differences between our patients and the source population in many respects, the area under the ROC curve was 0.73, which was comparable to that obtained in the study on the source population. CONCLUSIONS: The MSKCC nomogram provides a fairly accurate predicted probability for the likelihood of non-SLN metastases. Accordingly, it served as a useful tool for our Japanese patients with SLN metastases.
Authors: U Veronesi; G Paganelli; V Galimberti; G Viale; S Zurrida; M Bedoni; A Costa; C de Cicco; J G Geraghty; A Luini; V Sacchini; P Veronesi Journal: Lancet Date: 1997-06-28 Impact factor: 79.321
Authors: Marjolein L Smidt; Deborah M Kuster; Gert Jan van der Wilt; Frederik B Thunnissen; Kimberley J Van Zee; Luc J A Strobbe Journal: Ann Surg Oncol Date: 2005-10-26 Impact factor: 5.344
Authors: A E Giuliano; P I Haigh; M B Brennan; N M Hansen; M C Kelley; W Ye; E C Glass; R R Turner Journal: J Clin Oncol Date: 2000-07 Impact factor: 44.544
Authors: Amy C Degnim; Carol Reynolds; Gouri Pantvaidya; Shaheen Zakaria; Tanya Hoskin; Sunni Barnes; Margaret V Roberts; Peter C Lucas; Kevin Oh; Meryem Koker; Michael S Sabel; Lisa A Newman Journal: Am J Surg Date: 2005-10 Impact factor: 2.565
Authors: John A Olson; Linda M McCall; Peter Beitsch; Pat W Whitworth; Douglas S Reintgen; Peter W Blumencranz; A Marilyn Leitch; Sukamal Saha; Kelly K Hunt; Armando E Giuliano Journal: J Clin Oncol Date: 2008-07-20 Impact factor: 44.544
Authors: Antonio Piñero; Manuel Canteras; Arancha Moreno; Francisco Vicente; Julia Giménez; Ana Tocino; Edelmiro Iglesias; Sergi Vidal-Sicart; Luzdivina Santamaría; Miguel Lorenzo; Manuel García; Diego Ramirez Journal: Clin Transl Oncol Date: 2012-07-25 Impact factor: 3.405