Literature DB >> 22164456

Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography.

Mark Walsh1, Scott G Thomas, Janet C Howard, Edward Evans, Kirk Guyer, Andrew Medvecz, Andrew Swearingen, Rudolph M Navari, Victoria Ploplis, Francis J Castellino.   

Abstract

25-35% of all seriously injured multiple trauma patients are coagulopathic upon arrival to the emergency department, and therefore early diagnosis and intervention on this subset of patients is important. In addition to standard plasma based tests of coagulation, the thromboelastogram (TEG) has resurfaced as an ideal test in the trauma population to help guide the clinician in the administration of blood components in a goal directed fashion. We describe how thromboelastographic analysis is used to assist in the management of trauma patients with coagulopathies presenting to the emergency department, in surgery, and in the postoperative period. Indications for the utilization of the TEG and platelet mapping as point of care testing that can guide blood component therapy in a goal directed fashion in the trauma population are presented with emphasis on the more common reasons such as massive transfusion protocol, the management of traumatic brain injury with bleeding, the diagnosis and management of trauma in patients on platelet antagonists, the utilization of recombinant FVIIa, and the management of coagulopathy in terminal trauma patients in preparation for organ donation. The TEG allows for judicious and protocol assisted utilization of blood components in a setting that has recently gained acceptance. In our program, the inclusion of the perfusionist with expertise in performing and interpreting TEG analysis allows the multidisciplinary trauma team to more effectively manage blood products and resuscitation in this population.

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Mesh:

Year:  2011        PMID: 22164456      PMCID: PMC4679977     

Source DB:  PubMed          Journal:  J Extra Corpor Technol        ISSN: 0022-1058


  20 in total

Review 1.  Clinical utility of thromboelastography: one size does not fit all.

Authors:  Julie Wegner; Mark A Popovsky
Journal:  Semin Thromb Hemost       Date:  2010-10-26       Impact factor: 4.180

2.  The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care.

Authors:  S P Baker; B O'Neill; W Haddon; W B Long
Journal:  J Trauma       Date:  1974-03

3.  Can RapidTEG accelerate the search for coagulopathies in the patient with multiple injuries?

Authors:  Victor Jeger; Heinz Zimmermann; Aristomenis K Exadaktylos
Journal:  J Trauma       Date:  2009-04

Review 4.  Coagulopathy in trauma patients: importance of thrombocyte function?

Authors:  Ross A Davenport; Karim Brohi
Journal:  Curr Opin Anaesthesiol       Date:  2009-04       Impact factor: 2.706

5.  Thromboelastography to direct the administration of recombinant activated factor VII in a child with traumatic injury requiring massive transfusion.

Authors:  Cade M Nylund; Matthew A Borgman; John B Holcomb; Donald Jenkins; Philip C Spinella
Journal:  Pediatr Crit Care Med       Date:  2009-03       Impact factor: 3.624

6.  Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients.

Authors:  John B Holcomb; Charles E Wade; Joel E Michalek; Gary B Chisholm; Lee Ann Zarzabal; Martin A Schreiber; Ernest A Gonzalez; Gregory J Pomper; Jeremy G Perkins; Phillip C Spinella; Kari L Williams; Myung S Park
Journal:  Ann Surg       Date:  2008-09       Impact factor: 12.969

Review 7.  Advanced trauma life support, 8th edition, the evidence for change.

Authors:  John B Kortbeek; Saud A Al Turki; Jameel Ali; Jill A Antoine; Bertil Bouillon; Karen Brasel; Fred Brenneman; Peter R Brink; Karim Brohi; David Burris; Reginald A Burton; Will Chapleau; Wiliam Cioffi; Francisco De Salles Collet e Silva; Art Cooper; Jaime A Cortes; Vagn Eskesen; John Fildes; Subash Gautam; Russell L Gruen; Ron Gross; K S Hansen; Walter Henny; Michael J Hollands; Richard C Hunt; Jose M Jover Navalon; Christoph R Kaufmann; Peggy Knudson; Amy Koestner; Roman Kosir; Claus Falck Larsen; West Livaudais; Fred Luchette; Patrizio Mao; John H McVicker; Jay Wayne Meredith; Charles Mock; Newton Djin Mori; Charles Morrow; Steven N Parks; Pedro Moniz Pereira; Renato Sergio Pogetti; Jesper Ravn; Peter Rhee; Jeffrey P Salomone; Inger B Schipper; Patrick Schoettker; Martin A Schreiber; R Stephen Smith; Lars Bo Svendsen; Wa'el Taha; Mary van Wijngaarden-Stephens; Endre Varga; Eric J Voiglio; Daryl Williams; Robert J Winchell; Robert Winter
Journal:  J Trauma       Date:  2008-06

8.  A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries.

Authors:  Amy J Plotkin; Charles E Wade; Donald H Jenkins; Kimberly A Smith; Jody C Noe; Myung S Park; Jeremy G Perkins; John B Holcomb
Journal:  J Trauma       Date:  2008-02

9.  Early evaluation of acute traumatic coagulopathy by thrombelastography.

Authors:  Roger C Carroll; Robert M Craft; Russell J Langdon; Colin R Clanton; Carolyn C Snider; Douglas D Wellons; Patrick A Dakin; Christy M Lawson; Blaine L Enderson; Stanley J Kurek
Journal:  Transl Res       Date:  2009-05-03       Impact factor: 7.012

Review 10.  Thrombelastography and tromboelastometry in assessing coagulopathy in trauma.

Authors:  Pär I Johansson; Trine Stissing; Louise Bochsen; Sisse R Ostrowski
Journal:  Scand J Trauma Resusc Emerg Med       Date:  2009-09-23       Impact factor: 2.953

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  12 in total

1.  A Case of Successful Thromboelastographic Guided Resuscitation after Postpartum Hemorrhage and Cardiac Arrest.

Authors:  M Hurwich; D Zimmer; E Guerra; E Evans; T Shire; M Abernathy; J T Shreve; G R Kolettis; M T McCurdy; F J Castellino; M Walsh
Journal:  J Extra Corpor Technol       Date:  2016-12

Review 2.  Patient blood management in India - Review of current practices and feasibility of applying appropriate standard of care guidelines. A position paper by an interdisciplinary expert group.

Authors:  Ajay Gandhi; Klaus Görlinger; Sukesh C Nair; Poonam M Kapoor; Anjan Trikha; Yatin Mehta; Anil Handoo; Anil Karlekar; Jyoti Kotwal; Joseph John; Shashikant Apte; Vijay Vohra; Gajendra Gupta; Aseem K Tiwari; Anjali Rani; Shweta A Singh
Journal:  J Anaesthesiol Clin Pharmacol       Date:  2021-04-10

3.  When to correct coagulopathy in acute kidney injury?

Authors:  Manpreet Kaur; Babita Gupta; Nita D'souza; Seema Shende
Journal:  Anesth Essays Res       Date:  2012 Jul-Dec

Review 4.  Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy.

Authors:  Mark Walsh; Stephanie Fritz; Daniel Hake; Michael Son; Sarah Greve; Manar Jbara; Swetha Chitta; Braxton Fritz; Adam Miller; Mary K Bader; Jonathon McCollester; Sophia Binz; Alyson Liew-Spilger; Scott Thomas; Anton Crepinsek; Faisal Shariff; Victoria Ploplis; Francis J Castellino
Journal:  Curr Drug Targets       Date:  2016       Impact factor: 3.465

5.  Traumatic Abdominal Solid Organ Injury Patients Might Benefit From Thromboelastography-Guided Blood Component Therapy.

Authors:  Hao Wang; Richard D Robinson; Jessica L Phillips; Andrew Ryon; Scott Simpson; Jonathan R Ford; Johnbosco Umejiego; Therese M Duane; Bradley Putty; Nestor R Zenarosa
Journal:  J Clin Med Res       Date:  2017-04-01

6.  Effects of a novel low volume resuscitation solutions on coagulation and platelet function.

Authors:  Loren K Liebrecht; Jason Newton; Erika J Martin; Niluka Wickramaratne; Sudha Jayaraman; Jinfeng Han; Michel Aboutanos; Donald F Brophy; Martin J Mangino
Journal:  PLoS One       Date:  2019-05-01       Impact factor: 3.240

Review 7.  Viscoelastic Hemostatic Assays and Platelet Function Testing in Patients with Atherosclerotic Vascular Diseases.

Authors:  Matej Samoš; Ingrid Škorňová; Tomáš Bolek; Lucia Stančiaková; Barbora Korpallová; Peter Galajda; Ján Staško; Peter Kubisz; Marián Mokáň
Journal:  Diagnostics (Basel)       Date:  2021-01-19

Review 8.  Thromboelastography in Microsurgical Reconstruction: A Systematic Review.

Authors:  M Thakkar; A Rose; B Bednarz
Journal:  JPRAS Open       Date:  2022-01-11

9.  Abnormal whole blood thrombi in humans with inherited platelet receptor defects.

Authors:  Francis J Castellino; Zhong Liang; Patrick K Davis; Rashna D Balsara; Harsha Musunuru; Deborah L Donahue; Denise L Smith; Mayra J Sandoval-Cooper; Victoria A Ploplis; Mark Walsh
Journal:  PLoS One       Date:  2012-12-28       Impact factor: 3.240

10.  The Role of TEG and ROTEM in Damage Control Resuscitation.

Authors:  Jason B Brill; Megan Brenner; Juan Duchesne; Derek Roberts; Paula Ferrada; Tal Horer; David Kauvar; Mansoor Khan; Andrew Kirkpatrick; Carlos Ordonez; Bruno Perreira; Artai Priouzram; Bryan A Cotton
Journal:  Shock       Date:  2021-12-01       Impact factor: 3.454

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