| Literature DB >> 33478051 |
Matej Samoš1, Ingrid Škorňová2, Tomáš Bolek1, Lucia Stančiaková2, Barbora Korpallová1, Peter Galajda1, Ján Staško2, Peter Kubisz2, Marián Mokáň1.
Abstract
Platelets play crucial role in acute vascular atherosclerotic diseases, including myocardial infarction and stroke. Additionally, platelet aggregation is a key target of antiplatelet agents, forming the keystone of pharmacotherapy of various atherosclerotic cardiovascular diseases. Thromboelastography and thromboelastometry, representing currently available viscoelastic hemostatic assays (VHA), are designed as whole blood, real-time analyzers of clot formation and clot resolution. These assays could, in theory, overcome some limitations of currently available platelet function testing assays. This article reviews the current experience with the use of VHA for platelet function testing and for monitoring of the response to antiplatelet therapy.Entities:
Keywords: atherosclerotic vascular disease; platelet function testing; thromboelastography; thromboelastometry; viscoelastic hemostatic assays
Year: 2021 PMID: 33478051 PMCID: PMC7835760 DOI: 10.3390/diagnostics11010143
Source DB: PubMed Journal: Diagnostics (Basel) ISSN: 2075-4418